摘要
(1)目的探讨2型糖尿病(T2DM)肥胖患者血糖、血压与血皮质醇(F)水平的关系。(2)方法收集2型糖尿病患者146例,按腰臀比(WHR)分为非肥胖组(男WHR<0.9,女WHR<0.85)36例,肥胖组(男WHR≥0.9,女WHR≥0.85)110例,分别测定患者的血糖、血压及皮质醇。(3)结果肥胖患者组体质量、体质量指数(BMI)、腰围、臀围、腰臀比均高于非肥胖组,差异有统计学意义(P<0.05);肥胖组8∶00收缩压(8∶00SBP1)及舒张压(8∶00DBP1)、16∶00舒张压(16∶00DBP1)、次日8∶00收缩压(8∶00SBP2)及舒张压(8∶00DBP2)均高于非肥胖组,差异有统计学意义(P<0.05);肥胖组空腹血糖(FPG1)、晚餐前血糖、次日空腹血糖(FPG2)均高于非肥胖组,差异有统计学意义(P<0.05);肥胖组0∶00皮质醇(0∶00皮质醇)高于非肥胖组,差异有统计学意义(P<0.05)。8∶00皮质醇与8∶00收缩压及舒张压、16∶00收缩压及舒张压、次日8∶00收缩压及舒张压、空腹血糖、次日空腹血糖呈正相关(P<0.05);16∶00皮质醇与臀围、8∶00收缩压、16∶00收缩压、次日8∶00收缩压及舒张压、晚餐前血糖呈正相关(P<0.05);0∶00皮质醇与体质量、体质量指数、腰围、臀围、腰臀比、8∶00收缩压及舒张压、16∶00舒张压、次日8∶00舒张压、空腹血糖、次日空腹血糖呈正相关(P<0.05)。(4)结论肥胖可致糖尿病患者血糖、血压及皮质醇升高,且升高的血糖、血压与皮质醇呈正相关;全天皮质醇均参与了血压水平的升高;空腹血糖水平升高与8∶00和0∶00皮质醇有关,晚餐前血糖升高与16∶00皮质醇有关。
Objective To explore the relationship between blood glucose, blood pressure and serum cortisol level （F） in obese patients with type 2 diabetes mellitus（TSDM）.Methods Collected 146 cases of patients with type 2 diabetes,according to the waist to hip ratio （WHR） were divided into non obese group （male WHR〈0.9,or female WHR〈0.85） in 36 cases, obese group （maleWHR≥0.9,or female WHR≥0.85） in 110 cases,blood pressure and blood glucose,F in patients were determined respectively.Results Body weight,body mass index（BMI） ,waist circumference,hip circumference,waist to hip ratio in obese group were higher than that in non obese group（ P 〈0.05） ,the difference was statistically significant;The 8 ： 00 systolic blood pressure （8 ： 00 SBP1） and diastolic blood pressure （8 ： 00 DBP1）,16 ： 00 diastolic blood pressure（16 ： 00 DBP1）,the next day 8 ： 00 systolic blood pressure （8 ： 00 SBP2） and diastolic blood pressure （8 ： 00 DBPS） in obese group were higher than that in non obese group（ P 〈0.05）,the difference was statistically significant;The fasting blood glucose（FPG1）,blood glucose before dinner, the next day fasting blood glucose （FPG2） in obese group were higher than that in non obese group（ P 〈0.05）,the difference was statistically significant ; The 0 ： 00 cortisol （0 ： 00F） in obese group was higher than that in non obese group（ P〈0.05） ,the difference was statistically significant.The 8 ： 00 eortisol was positively correlated with 8 ： 00 systolic blood pressure and diastolic blood pressure,16 ： 00 systolic blood pressure and diastolic blood pressure,the next day 8 ： 00 systolic blood pressure and diastolic blood pressure, fasting blood glucose, the next day fasting blood glucose（ P 〈0.05）;The 16 ： 00 cortisol was positively correlated with hip circumference,8 ：00 systolic blood pressure, 16 ： 00 systolic blood pressure, 8 ： 00 systolic blood pressure and diastolic blood pressure of the next day
作者
刘长丽
金秀平
王颖
王晓迪
LIU Changli JIN Xiuping WANG Ying et al(North China University of Science and Technology Affiliated to Hospital, Tangshan 063000, Chin)
出处
《华北理工大学学报（医学版）》
2017年第4期290-294,共5页
Journal of North China University of Science and Technology：Health Sciences Edition
关键词
2型糖尿病
肥胖
皮质醇
血糖
血压
Diabetes mellitus.Type 2.Obesity.Cortisol.Blood glucose. Blood pressure
