摘要
目的:探讨2型糖尿病肥胖患者的主要临床指标特征及中医的病机关键。方法:采用随机对照研究的方法观察100例2型糖尿病(T2DM)肥胖和非肥胖患者的年龄、病程、体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、餐后2h血糖(PBG),以及计算胰岛素抵抗指数(HOMA-IR)。肥胖T2DM辨证分型统计。结果:肥胖组与对照组年龄、病程、FPG及HbA1c比较,差异无统计学意义(P>0.05);肥胖组BMI(26.0±3.67)kg/m2、PBG(15.17±3.79)mmol/L、FINS(10.77±7.93)μU/mL及HOMA-IR(3.64±3.27),与对组BMI(22.8±3.12)kg/m2、PBG(13.77±4.11)mmol/L、FINS(8.97±9.03)μU/mL及HOMA-IR(2.29±1.44)比较,差异有统计学意义(P<0.01,P<0.05);肥胖组患者更易出现湿热困脾证。结论:肥胖的T2DM患者中存在高胰岛素血症、IR以及餐后血糖控制不佳的情况;湿热困脾是肥胖的T2DM的病机关键。
Objective:To study the main characteristics of the clinical indicators and the key TCM pathogenesis of the obese T2DM patients. Methods: A randomized control study is used to observe 100 cases of type 2 diabetes mellitus (T2DM) in obese and non obese patients,whose age,duration of disease,body mass index (BMI),fasting plasma glucose (FPG),fasting insulin (FINS),glycosylated hemoglobin (HbA1c),2h postprandial blood glucose (PBG) are observed. Also the insulin resistance index (HOMA-IR) is calculated and the statistics of the Obese T2DM syndrome type is made. Results: The age,duration of disease ,FPG and HbA1c of obese group and control group are compared to be no statistically significant difference (P0.05); obese group BMI (26.0±3.6) kg/m2,PBG (15.17±3.79) mmol / L,FINS (10.77±7.93) μU / mL,and HOMA-IR (3.64±3.27),compared with the control group BMI (22.8±3.1) kg/m2,PBG (13.77±4.11) mmol / L,FINS (8.97±9.03) μU / mL,and HOMA-IR (2.29±1.44),the difference is statistically significant (P0.01,P0.05); obese patients are more prone to Damp-heat trapped spleen syndrome.Conclusion Hyperinsulinemia,IR,and poor control of postprandial blood glucose exist in the obese T2DM patients; Damp-heat trapped spleen is the key pathogenesis of the the obese T2DM patients.
出处
《中华中医药学刊》
CAS
2010年第9期1963-1964,共2页
Chinese Archives of Traditional Chinese Medicine
关键词
2型糖尿病
肥胖患者
血糖
胰岛素
中医辨证
type 2 diabetes
obese patients
blood glucose
insulin
TCM syndrome differentiation