摘要
目的探讨齐墩果酸对氟伐他汀在大鼠体内的药动学影响。方法将16只健康大鼠随机分为单药组(5.0 mg·kg^(-1)氟伐他汀)和联合用药组(5.0 mg·kg^(-1)氟伐他汀+60 mg·kg^(-1)齐墩果酸),单药组和联合用药组分别灌胃空白溶剂和齐墩果酸5 d,每天1次,第6天2组均给予氟伐他汀灌胃。给药后不同时间点采血,LC-MS测定大鼠体内血药浓度,比较2组间主要的药动学参数。结果与单药组比较,联合用药组氟伐他汀主要药动学参数Cmax、AUC0-t显著上升,组间比较差异具有统计学意义(P<0.05)。结论联合应用齐墩果酸可能影响大鼠体内氟伐他汀的药动学特性。
OBJECTIVE To explore the effect of oleanolic acid（OA） on the metabolism of fluvastatin in rats. METHODS Sixteen health rats were randomly divided into two groups： the single group（fluvastatin 5.0 mg·kg^（-1）） and the combined group（fluvastatin 5.0 mg·kg^（-1）＋OA 60 mg·kg^（-1））. The single group were administrated with blank solution while the combined group were administrated with the same volume of OA, the administration period of 5 d. At the sixth day, both groups were administrated with fluvastatin, plasma concentrations of fluvastatin were determined by LC-MS. The main pharmacokinetic parameters were calculated and compared. RESULTS The main pharmacokinetic parameters（Cmax, AUC0-t） of the combined group showed increased remarkably compared with the single group. Statistically significant difference was showed between groups（P〈0.05）. CONCLUSION OA can affect the pharmacokinetic parameters of fluvastatin in rats.
作者
杨茗钫
徐文炜
程晓华
YANG Mingfang XU Wenwei CHENG Xiaohua(The First Affiliated Hospital of Nanchang University, Nanchang 330006, China Institute of Clinical Pharmacology of Nanchang University, Nanchang 330006, China)
出处
《中国现代应用药学》
CAS
CSCD
2017年第6期811-814,共4页
Chinese Journal of Modern Applied Pharmacy
基金
"重大新药创制"国家科技重大专项(2011ZX09302-007-03)
江西省青年科学基金计划项目(20142BAB215019)
江西省卫生计生委科技计划项目(20175136)
