摘要
单胺类氧化酶A(MAOA)能够催化包括5-羟色胺在内的多种胺类神经递质的降解过程。这些神经递质异常与许多精神障碍类疾病紧密相关。研究发现MAOA具有多态性,拥有低活性等位基因(MAOA-L)和高活性等位基因(MAOA-H)。本综述通过参考有关早期应激的人类及动物模型的研究,分析了早期应激与MAOA多态性对个体行为和情感环路的影响。分析表明,MAOA-L相对于MAOA-H更具有可塑性,在早期的不利环境中会增加成年后暴力行为发生的风险,而在早期积极有利的环境中则会减少暴力行为的发生;MAOA-L在神经情感环路更易出现情感加工与认知执行功能异常,从而使MAOA-L相对于MAOA-H更具有环境易感性。
Monoamine oxidase A （MAOA） can catalyze the degradation of a variety of amine neurotrans- mitter, including serotonin. The abnormalities of these neurotransmitter are closely associated with many psychiatric disorders. Studies have found that MAOA is polymorphic, with a low activity variant （MAOA-L）, and a high activity variant （MAOA-H）. In this review, through the studies of early stress on human and animal models, the effects of early stress and MAOA polymorphism on the behavior and emotional loop of individuals are analyzed. Analysis shows that, MAOA-L, versus MAOA-H, is more plastic. In early adverse environment, MAOA-L will increase the risk of adult violence, and in the early of energetically favorable environment will reduce the incidence of vio- lence. Abnormality is more likely to occur in the emotional processing and cognitive function in the neural affective loop of individuals with MAOA-L, which makes them more environmentally susceptible than those with MAOA-H.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2017年第7期580-584,共5页
Chinese Mental Health Journal
基金
国家自然科学基金(81571324)
辽宁省沈阳市科技计划项目(F16-205-1-53)
