摘要
目的探讨血清白介素17及干扰素γ水平与急性冠脉综合征(ACS)患者心功能的相关性。方法选取2014年1月—2017年1月常州市第四人民医院心内科收治的ACS患者62例,根据疾病类型分为A组[急性心肌梗死(AMI)]与B组[不稳定型心绞痛(UAP)],每组31例;另选取同期于常州市第四人民医院体检健康者31例作为对照组。比较3组受试者血清白介素17和干扰素γ水平及心功能指标;血清白介素17、干扰素γ水平与ACS、AMI患者心功能指标的相关性分析采用Pearson相关性分析。结果 A、B组患者血清白介素17、干扰素γ水平高于对照组(P<0.05);A组患者血清干扰素γ水平高于B组(P<0.05)。A组患者左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)低于对照组、B组,左心室舒张末期内径(LVEDD)长于对照组、B组(P<0.05)。Pearson相关性分析结果显示,血清白介素17水平与ACS患者LVEF呈负相关(r=-0.301,P<0.05);血清白介素17水平与AMI患者LVEF呈负相关(r=-0.523,P<0.05),血清干扰素γ水平与AMI患者LVEF、LVEDD呈负相关(r值分别为-0.125、-0.011,P<0.05)。结论血清白介素17及干扰素γ水平与ACS患者心功能密切相关,可在一定程度上反映ACS患者病情严重程度。
Objective To investigate the correlations of serum levels of IL-17 and INF-7 with cardiac function of patients with acute coronary syndrome. Methods From January 2014 to January 2017 , a total of 62 patients with acute coronary syndrome were selected in the Department of Cardiology, the Fourth People＇s Hospital of Changzhou,and they were divided into A group （with acute myocardial infarction） and B group （with unstable angina pectoris） according to illness types, each of 31 cases; meanwhile a total of 31 healthy people admitted to this hospital for physical examination were selected as control group. Serum levels of IL-17 and INF-7 and index of cardiac function were compared among the three groups, Pearson correlation analysis was used to analyze the correlations of serum levels of IL-17 and INF-7 with index of cardiac function in patients with acute coronary syndrome and in patients with acute myocardial infarction. Results Serum levels of IL-17 and INF-7 of A group and B group were statistically significantly higher than those of control group, meanwhile serum INF-7 level of A group was statistically significantly higher than that of B group （ P 〈 0. 05 ） . LVEF and LVFS of A group were statistically significantly lower than those of control group and B group, while LVEDD of A group were statistically significantly longer than those of control group and B group （ P 〈0. 05 ）. Pearson correlation analysis results showed that, serum IL-17 was negatively correlated with LVEF of patients with acute coronary syndrome （ r = - 0. 301, P 〈0. 05） ; serum IL-17 was negatively correlated with LVEF of patients with acute myocardial infarction （ r = -0. 523,P 〈0. 05）,meanwhile serum INF-7 level was negatively correlated with LVEF （r = -0.125） and LVEDD （ r = -0.011） of patients with acute myocardial infarction, respectively （ P 〈 0. 05 ） .Conclusion Serum levels of IL-17 and INF-7 are significantly correlated with cardiac function of patients with ac
出处
《实用心脑肺血管病杂志》
2017年第6期6-9,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
急性冠脉综合征
白介素17
干扰素Γ
心功能
Acute coronary syndrome
Interleukin - 17
Interferon - gamma
Cardiac function
