摘要
目的:探讨急性冠状动脉综合征(ACS)患者冠状动脉Gensini评分与血清超敏C反应蛋白(hsCRP)水平的相关性。方法:回顾性分析2013-08-2014-08我院内科治疗的135例ACS患者临床资料,依据Gensini评分判定冠状动脉病变的严重程度,并将其分为3组,重度病变组46例,中度病变组45例,轻度病变组44例,另选择冠状动脉造影(CAG)无明显异常者45例作为对照组,观察4组冠状动脉狭窄程度,并对比4组Gensini评分,以Logistic回归模型、Spearman相关性分析判定各危险因素与Gensini评分的关系。结果:与对照组比较,ACS各组血清hs-CRP水平均明显升高,差异有统计学意义(P<0.05),以Gensini评分为因变量,以年龄、SBP、hs-CRP、低密度脂蛋白(LDL-C)、空腹血糖(FPG)为自变量,实施多元Logistic回归分析,提示年龄、SBP、hs-CRP、LDL-C、FPG是冠状病变狭窄程度的独立危险因素。实施Spearman相关性分析,将Gensini评分作为变量,判定Gensini评分与hs-CRP水平的相关性,提示hs-CRP水平与Gensini评分呈正相关(P<0.01,r=0.915)。结论:ACS患者通过检测血清hs-CRP水平,能够对冠状动脉狭窄程度进行预测,方便快速,可以为临床提供诊断依据。
Objective：To investigate the relationship between Gensini score（coronary artery score）and serum hs-CRP（C）level in patients with acute coronary syndrome（ACS）.Method：The clinical data of 135 patients with ACS from August 2014 to August 2013 were retrospectively analyzed.The patients were divided into three groups according to Gensini score,46 patients with severe lesions,45 patients with moderate lesions,44 patients with mild lesions,and four patients with coronary artery stenosis.Result：Serum hs-CRP level in ACS group was significantly higher than that in control group（P〈0.05）,the Gensini score was the independent risk factor of age,hs-CRP（systolic blood pressure）,LDL-C,FPG（low density lipoprotein）and Logistic（fasting blood glucose）as independent risk factors for SBP,hs-CRP,FPG and LDL-C.Gensini correlation analysis was carried out,and the Spearman score was used as a variable to determine the correlation between Gensini score and hs-CRP level,which indicated that hs-CRP level and Gensini score were positively correlated（P〈0.01,r=0.915）.Conclusion：The level of serum hs-CRP in patients with ACS can forecast the extent of coronary stenosis,which is simple and effective,and it can provide diagnosis basis for clinic.
出处
《临床急诊杂志》
CAS
2015年第12期944-946,共3页
Journal of Clinical Emergency
