摘要
目的探讨ROC曲线评价血清胱抑素C(CysC)对原发性高血压早期轻度肾损害的诊断价值。方法选取原发性高血压血肌酐(Cr)正常患者290例,检测血清CysC及尿微量白蛋白/尿肌酐比值(mAlb/Cr,ACR),尿ACR≥30 mg/g为病例组,ACR<30 mg/g为对照组,运用ROC曲线评价血清CysC诊断高血压轻度肾损害的诊断价值。结果血清CysC水平病例组与对照组比较差异有统计学意义(P<0.05);CysC诊断高血压早期轻度肾损害的ROC曲线下面积为0.944,95%可信区间0.912~0.968。灵敏度92.00%,特异度89.36%,阳性预测值90.2%,阴性预测值91.3%。结论血清CysC水平升高能反映原发性高血压患者早期轻度肾损害,血清CysC>1.22 mg/L可作为诊断切点。
Objective To investigate the diagnosis value of ROC curve on the serum cystatin C （CysC） of early renal func-tion injury in patients with essential hypertension. Methods 290 cases of essential hypertension persons were divided into two groups by the results of urinary Albumin/Creatinine ratio（ ACR）. The diagnostic cut-off value was determined by ROC curve. Results When the cut-off value was 1.22, the ROC curve had the largest area under the curve（AUC） of 0. 944,the sensitivity was 9 2 % ,specificity was 89.36% , the positive predictive value was 90. 2 % and the negative predictive value was 91.3%. Conclusion The value of serum Cys C which is higher than 1.22 mg/1 can be used as important indicator for early diagnosis of kidney injury in patients with essential hypertension.
出处
《海军医学杂志》
2017年第3期275-277,共3页
Journal of Navy Medicine
