摘要
目的探讨辣椒素对变应性鼻炎大鼠鼻黏膜形态、P物质表达的影响及作用机制。方法建立变应性鼻炎动物模型,采用辣椒素滴鼻,记录大鼠喷嚏次数、抓鼻次数、流涕情况评分叠加计分。对比正常组、未治疗组、治疗组鼻黏膜形态,对比治疗后鼻黏膜肥大细胞、P物质含量变化。结果治疗后治疗组变应性鼻炎症状明显缓解(P<0.05),治疗组肥大细胞、P物质含量较未治疗组明显减少(P<0.05)。结论辣椒素对变应性鼻炎有治疗作用,其作用机制与减少P物质含量、降低IgE介导的I型变态反应相关。
Objective To investigate the effect of capsaicin on nasal mucosal morphology and substance P expression in allergic rhinitis rats and its mechanism. Methods Animal model of allergic rhinitis was established. Capsaicin was used intranasally, and the number of sneezes and catching nose, runny nose situation were recorded and scored, and the scores were superimposed. The nasal mucosal morphology among normal group, untreated group and treated group was compared. The changes of nasal mucosa mast cells and substance P content after treatment were compared. Results The symptoms of allergic rhinitis in the treatment group after treatment were significantly relieved（P〈0.05）. The nasal mucosa mast cells and the content of substance P in the treatment group were significantly lower than those in the untreated group（P〈0.05）. Conclusion Capsaicin has a therapeutic effect on allergic rhinitis, and its mechanism is related to reduce the content of substance P and reducing IgE-mediated type Ⅰ allergic reaction.
出处
《中国现代医生》
2017年第16期33-35,F0003,共4页
China Modern Doctor
关键词
辣椒素
P物质
变应性鼻炎
Capsaicin
Substance P
Allergic rhinitis
