摘要
目的 探讨乌司他丁对高龄髋关节置换术患者术后凝血功能的影响.方法 以浙江省荣军医院收治的120例行髋关节置换术的高龄患者为研究对象,将其随机分为2组,分别为观察组和对照组,每组各60例.给予对照组口服拜瑞妥进行治疗,在对照组基础上给予观察组静脉滴注乌司他丁进行治疗.检测2组患者的临床表现和各项凝血指标,并进行比较.结果 观察组和对照组2组患者术后2d的TT、APTT、PT、DD和FIB相比较,数据差异具有统计学意义（t=-5.300,-2.319,-2.409,-2.325,-3.567;P〈0.05）.观察组和对照组2组患者术后5d的CRP、TXB2、住院时间和总引流量相比较,观察组低于对照组,数据差异具有统计学意义（t=-2.529,-2.082,-3.388,-2.887;P〈0.05）.观察组和对照组2组患者不良反应情况相比较,观察组患者出现血尿素升高和血肌酐升高的比率比对照组低,但是出现恶心的比率比对照组高,数据差异具有统计学意义（χ2=5.217,5.926,8.571;P均〈0.05）.观察组和对照组2组患者不良事件情况相比较,观察组患者发生下肢深静脉血栓的概率比对照组低,数据差异具有统计学意义（χ2=8.571,P〈0.05）.结论 髋关节置换术患者采用静脉滴注乌司他丁进行治疗,能降低下肢深静脉血栓的发生率,改善患者术后的高凝状态,对患者免疫力的恢复和伤口的愈合具有良好的效果.
Objective To explore the effect of ulinastatin on coagulation function of elderly patients after hip replacement.MethodsTotally 120 patients undergoing elective hip replacement in our hospital were chosen.According to the stratified randomization method, all patients were divided into observation group and control group with 60 in each.The control group received oral Xarelto combined with other conventional treatment, while the observation group received ulinastatin on the basis of the treatment regimen of the control group.The coagulation parameters and clinical manifestations were compared between two groups.ResultsTwo days after operation, the TT, APTT, PT, DD and FIB between the two groups showed statistically significant difference （t=-5.300,-2.319,-2.409,-2.325,-3.567;P〈0.05）.The hospital stay,CRP,TXB2 and total drainage volume in observation group 5d after operation were lower than those in control group, between the two groups showed statistically significant difference （t=-2.529,-2.082,-3.388,-2.887;P〈0.05）.The patients with elevated blood urea and serum creatinine in observation group were obviously less than that of control group, but the patients with nausea in observation group were obviously higher than those in control group,between the two groups showed statistically significant difference （χ2=5.217,5.926,8.571;P〈0.05）.The patients with deep vein thrombosis in observation group were obviously higher than those in control group,between the two groups showed statistically significant difference （χ2=8.571, P〈0.05）.ConclusionUlinastatin can significantly improve the hypercoagulable state of patients after hip replacement and reduce the incidence of deep vein thrombosis, and plays an important role in promoting wound healing and immunity recovery.
作者
孙贤杰
张新根
石钢
方铭
SUN Xian-jie ZHANG Xin-gen SHI Gang FANG Ming(Department of Orthopaedics, Zhejiang Rongjun Hospital, Jiaxing 314000, China)
出处
《中国生化药物杂志》
CAS
2017年第6期155-157,共3页
Chinese Journal of Biochemical Pharmaceutics
