摘要
目的 研究利伐沙班与低分子肝素对髋部骨折患者下肢深静脉血栓的预防作用对比.方法 四川省成都市第二人民医院骨科2016年3月-2017年3月收治髋部骨折行膝关节置换及全髋关节置换的住院患者的158例患者,按随机数表法随机分为观察组与对照组,每组79例,观察组接受新型抗凝药利伐沙班治疗,对照组接受低分子量肝素钙治疗.观察2组治疗方式对深静脉血栓的预防作用以及不良反应.结果 与对照组比较, 观察组深静脉血栓形成（deep vein thrombosis,DVT）发生率较低且2组比较差异显著,具有统计学意义（P〈0.05）.观察组与对照组比较凝血酶原时间（prothrombin time,PT）、活化部分凝血活酶时间（activated partial thromboplastin time,APTT）术前、术后第2天、5天均不具有明显差异,无统计学意义.观察组与对照组比较血肿、皮下瘀斑、切口渗血均无明显差异.结论 利伐沙班在人工关节置换术后预防深静脉血栓形成效果较低分子量肝素钙更好,且凝血功能影响小.
Objective To study the new anticoagulants, felling shaaban joint care used in joint replacement for prevention of deep vein thrombosis.MethodsThe Second People＆#39;s Hospital of Chengdu orthopaedics in March 2016 to March 2017 were hospitalized patients with knee joint replacement and total hip replacement of the 158 patients, according to the stochastic indicator method were randomly divided into observation group and control group, 79 cases in each group, the observation group received new anticoagulants, cutting class joint care, the control group accepted low molecular weight heparin calcium in combination with care.Observe two groups of treatment of deep vein thrombosis prevention effect and adverse reactions.ResultsCompared with control group, the observation group with lower incidence of DVT and difference comparing the two groups have statistical significance （P〈0.05）.Observation group compared with control group, PT, APTT, preoperative and postoperative 2 day, five days did not have obvious difference, no statistical significance.Observation group compared with control group, subcutaneous ecchymosis, incision hematoma bleeding had no obvious difference）.ConclusionThe laval shaaban joint care to prevent deep venous thrombosis after artificial joint replacement effect of low molecular weight heparin calcium is better, and coagulation function effect is small.
作者
蒋华
李庆
JIANG Hua LI Qing(Department of Orthopedics, the Second people＇s Hospital of Chengdu, Chengdu 404000, Chin)
出处
《中国生化药物杂志》
CAS
2017年第6期40-42,共3页
Chinese Journal of Biochemical Pharmaceutics
