摘要
miRNA(MicroRNA)为一类非编码的微小核糖核酸,能间接的发挥调控蛋白翻译的作用,目前在现代解剖意义上的肾脏中已发现有大量miRNA与中医藏象理论中"肾藏象"的生理功能紧密相关。该文通过文献整理与理论评述,从传统中医学"肾藏精"理论出发,探讨miRNA对中医药防治糖尿病肾病的意义。糖尿病肾病是糖尿病导致的危害性最大的一种慢性并发症,以微血管病变进而引起肾小球硬化为重要特点。临床上中医药治疗对于糖尿病肾病控制症状、改善病情有着显著作用,通过对相关miRNA的研究有助于进一步深入理解中医治疗的现代物质基础。今后miRNA对于糖尿病肾病的相关研究必将越来越受到人们的重视。
miRNA（ MicroRNA）,as a kind of tiny non-coding RNA,can affect protein translation indirectly. Currently,there are a lot of miRNAs in the kidney having been found to have a connection with the with the physiological functions of kidney（ Shen） in TCM. In this paper,through literature and theoretical review,based on the traditional Chinese medicine theory that kidney（ Shen） in TCM stores essence,the meaning of prevention and treatment of diabetic nephropathy in TCM with miRNA will be discussed. Diabetic nephropathy（ DN） is one of the most harmful chronic complications caused by diabetes. And the glomerular sclerosis caused by microvascular lesions is the important feature of DN. Traditional Chinese medicine can ameliorate symptoms and improve disease control obviously in diabetic nephropathy. Moreover,it is certain to further understand the modern material basis of treatment in TCM from researches of miRNA. And the studies of miRNA in DN will be paid more and more attentions on.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2017年第5期1164-1166,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81573907)
关键词
糖尿病肾病
MIRNA
肾藏精
Diabetic nephropathy
miRNA
Kidney（Shen） in TCM stores essence
