摘要
目的探讨可溶性羧甲基壳聚糖-浓缩血小板复合止血材料在新西兰白兔耳动脉出血模型的止血效果。方法将32只新西兰白兔随机分为4组:可溶性羧甲基壳聚糖/血小板复合止血材料组(CC/PRP)、羧甲基壳聚糖组(CC)、冻干血小板组(FDP)及空白对照组(BC),8只/组,建立耳动脉出血模型,并将对应的止血材料敷于新西兰白兔耳部出血创面,观察各组材料的止血时间和出血量。结果对于建立的耳动脉出血模型,各组材料均可完成止血。CC/PRP组、CC组及FDP组的止血时间和出血量均明显少于BC组,差异有统计学意义(P<0.05);而CC组与FDP组间止血时间及失血量差异显著(P<0.05);与单独使用CC或FDP相比,CC/PRP组止血时间显著性缩短,出血量明显减少,差异有统计学意义(P<0.05)。结论羧甲基壳聚糖和PRP联合使用对新西兰白兔耳动脉出血具有更加显著的止血效果。
Objective To study the hemostatic effect of absorbable carboxy-methyl chitosan composite biomaterials associated with platelet rich plasma （CC/PRP） on an artery wound by means of New Zealand rabbit models. Methods Trau- matic artery bleeding models were established in 32 rabbits. The rabbits were divided into 4 groups randomly： one group u- sing carboxymethyl chitosan/concentrated platelets （group CC/PRP） ; one group using carboxymethyl chitosan （group CC） ; one group using freeze-dried platelets （ group FDP） and one blank control group （ group BC）. Every group included 8 rabbits with auricular artery wound. The hemostatic time and the blood loss on the wounds were observed. Results In all the groups, hemostasis was achieved. In groups CC/PRP, CC and PRP, hemostasis was obtained more rapidly and there was less blood loss than that in group BC（P〈0. 05） ; There were significant differences in the hemostatic ability between group CC and FDP（P〈0. 05）. Compared with CC and FDP used alone during hemostasis, there was less blood loss and bleeding time in synergistic actions of these （P〈0. 05）. Conclusion The synergistic actions of CC and PRP possess a better hemo- static effect on wounds with induced artery bleeding.
作者
张卫
单桂秋
黎诚耀
程飚
林放
施琳颖
王玲
杨域
ZHANG Wei SHAN Guiqiu LI Chengyao CHENG Biao LIN Fang SHI Lin- ying WANG Lin YANG Yul,(Southern Medical University, Guangzhou 510010, China Department of Blood Trans- fusion, Guangzhou General Hospital of Guangzhou Military Command Guangzhou General Hospital of Guangzhou Military Command.)
出处
《中国输血杂志》
北大核心
2017年第5期504-507,共4页
Chinese Journal of Blood Transfusion
