摘要
目的观察纤维蛋白胶（FS）干粉对严重创伤创面的止血效果,并寻找最佳有效剂量.方法在新西兰大白兔肝脏表面制作面积为1 cm^2的圆形创面,应用不同剂量的FS干粉,通过出血时间和出血量检测,找出最适宜的FS干粉剂量,同时与明胶海绵、甲壳素棉、普通纱布等的止血效果进行比较.结果 FS 10 mg/cm^2组的止血时间和出血量与FS 8 mg/cm^2组相比有显著性差异（P＜0.05）,与FS 12 mg/cm^2组无显著性差异.FS 10 mg/cm^2组止血时间最短,出血量最少,与明胶海绵、甲壳素敷料和普通纱布有显著性差异（P＜0.05～0.01）.结论 FS干粉的止血效果优于明胶海绵、甲壳素敷料以及普通纱布等,最适剂量为10mg/cm^2.
Objective To investigate the hemostatic effect of fibrin sealant （FS） powder on severe wound surface and find out the minimum effective dosage. Methods 1 cm^2 round wound surface was made on the liver of New Zealand white rabbits. Different dosages of FS powder were administrated on the wound surface. Bleeding time and bleeding volume were examined to find out optimized dosage. Hemostatic effect of FS powder was observed and compared with chitin cotton, gelfoam and normal gauze. Results - Bleeding time （0.57±0.21 min）and bleeding volume （0.35±0.29 ml）of FS 10 mg/cm^2 group were obviously different from FS 8 mg/cm^2 group （ P 〈0.05）, not significantly different from FS 12 mg/cm^2 group. FS 10 mg/cm^2 group got the shortest bleeding time and the lowest bleeding volume, which was obviously different from chitin cotton, gelfoam and gauze groups （ P 〈0.05 -0. 01）. Conclusion The hemostatic effect of FS powder is better than gelfoam, chitin cotton and gauze and its optimized dosage is 10 mg/cm^2.
出处
《中国康复理论与实践》
CSCD
2006年第4期307-308,共2页
Chinese Journal of Rehabilitation Theory and Practice
基金
军队"十一五"指令性课题基金资助项目(No.05XJM004)。
关键词
纤维蛋白胶
干粉
止血
剂量
fibrin sealant
powder
hemostasis
dosage
