摘要
[目的]系统评价自血疗法治疗慢性荨麻疹的疗效与安全性。[方法]计算机检索建库至2016年5月中国知网(CNKI)、万方医学网和中国生物医学文献数据库(SinoMed)、PubMed中关于自血疗法治疗慢性荨麻疹的随机对照试验研究文献,由2名研究者按照纳入与排除标准独立进行文献筛选、资料提取和质量评价,采用Review Manager 5.3软件进行Meta分析。[结果]纳入符合标准的10个RCT文献,涉及686例病人。采用固定效应模型分别对有效率和复发率进行Meta分析。有效率合并效应量RR=1.13,95%CI[1.07,1.19](Z=4.56,P<0.000 01),自血疗法组有效率优于常规治疗组。复发率合并效应量RR=0.32,95%CI[0.21,0.48],Z=5.61(P<0.000 01),自血疗法组复发率低于常规治疗组。[结论]与常规治疗相比,自血疗法疗效更优,且复发率低。但由于纳入文献数量较少,质量较低,当前证据尚不能确定完全适用于临床。
Objective：To systematic review the curative effect and safety of autohemotherapy for treating chronic urticaria.Methods：Randomized controlled trials were searched among China Knowledge Network （CNKI）,Wanfang database,SinoMed,and PubMed on autohemotherapy for treating chronic urticaria from the retrieval database to May 2016.Two investigators according to the inclusion and exclusion criteria carried out the literature screening,data extraction,and quality evaluation independently.Meta-analysis was performed by using Review Manager 5.3 software.Results：A total of 10 RCT literatures were included in the standard,involving 686 patients.Meta-analysis was performed on the efficiency and recurrence rate by using the fixed effect model,respectively.Efficiency combined with effect volume was RR=1.13,95%CI[1.07,1.19] （Z=4.56,P〈0.000 01）.The effective rate in autohemotherapy group was better than that in conventional treatment group.The recurrence rate combined with effect volume was RR=0.32,95%CI[0.21,0.48],Z=5.61 （P〈0.000 01）,and the recurrence rate in autohemotherapy group was lower than that in conventional treatment group.Conclusions：Compared with conventional therapy,the curative effect of autohemotherapy was better,and the recurrence rate was lower.However,due to the small number of included literatures and the low quality,the current evidences were not yet fully applicable to clinical practice.
出处
《护理研究（上旬版）》
2017年第7期2351-2355,共5页
Chinese Nursing Researsh
关键词
慢性荨麻疹
自血疗法
随机对照试验
META分析
系统评价
疗效
安全性
chronic urticaria
autohemotherapy
randomized controlled trials
meta-analysis
systematic evaluation
curative effect
safety
