摘要
目的探讨急性时相反应、凝血，纤溶系统与慢性荨麻疹的关系。方法用酶联免疫吸附法测定53例慢性荨麻疹患者及25例健康人血清白介素6（IL一6）、淀粉样A物质（SAA）水平，同时用免疫比浊法测定血清超敏c反应蛋白（Hs—CRP）及血浆D一二聚体水平，比较两组之间的差异。慢性荨麻疹患者按症状严重程度分为3级（3组），分析各检测项目之间的相关性以及各检测项目与慢性荨麻疹症状严重程度的关系。结果慢性荨麻疹患者组IL-6（10．70±4．94ng／L）、SAA[M（P25，P75）为4．92（8．22，12．51）μg／L]、D-二聚体（222．32±163．69μg／L）水平均高于健康对照组[分别为7．49±3．41ng／L、2．11（1．21，2．83）μg／L、104．72±43．12μg，L]，两组差异均有统计学意义（P〈0．05）；Hs—CRP水平[0．30（0．10，1．40）mg／L]与健康对照组[0．30（0．10，O．55）mg／L]比较，差异无统计学意义（P〉0．05）。慢性荨麻疹患者IL-6水平与Hs—CRP、SAA、D-二聚体水平及症状严重程度均无显著相关性（均P〉0．05），Hs—CRP水平与SAA水平（r=0．67，P〈0．01）、Hs—CRP水平与D-二聚体水平（r=0．49，P〈0．01）、SAA水平与D一二聚体水平（r=0．38，P〈0．01）均呈显著正相关；Hs—CRP、SAA、D-二聚体水平与症状严重程度呈显著正相关（r值分别为0．63、0．62、0．47，均P〈0．01）。结论慢性荨麻疹患者存在急性时相反应及凝血系统的激活，两者的发生可能存在相关性。
Objective To evaluate the relationship of acute-phase response and coagulation/fibrinolysis with chronic urticaria （CU）. Methods Fifty-three patients with CU and twenty-five healthy human controls were enrolled in this study. Venous blood samples were collected from all of these subjects. Then, enzyme-linked immunosorbent assay was carried out to measure the serum levels of interleukin-6 （IL-6） and amyloid protein A （AA）, and immunoturhidimetry to determine the levels of serum high sensitive C-reactive protein （Hs-CRP） and plasma D-dimer. The patients with CU were classified into three groups according to the severity of clinical symptoms. The levels of serum IL-6 and plasma D-dimer were given in mean ± standard deviation, and those of serum AA and Hs-CRP in mean （25th percentile, 75th percentile ）. Rank sum test and t test were performed to compare these parameters between the patients and controls, and Spearman rank correlation analysis was conducted to study the relationship among these parameters as well as between these parameters and symptom severity in these patients. Results The levels of serum IL-6, serum AA and plasma D-dimer were （10.70 ± 4.94） ng/L, 4.92 （8.22, 12.51 ） μg/L, and （222.32 ± 163.69） μg/L respectively in the patients with CU, significantly higher than those in the healthy controls （（7.49 ± 3.41） ng/L, 2.11 （1.21, 2.83） μg/L, （104.72 ± 43.12） I^g/L, respectively, all P〈 0.05）, while no significant differences were observed between the patients and controls in the level of serum Hs- CRP （0.30 （0.10, 1.40） mg/L vs. 0.30 （0.10, 0.55） mg/L, P〉 0.05）. In patients with CU, the levels of serum IL-6 were unrelated to those of serum Hs-CRP, serum AA, or plasma D-dimer （all P 〉 0.05）, whereas a positive correlation was observed between the levels of serum Hs-CRP and AA （r = 0.67, P 〈 0.01）, serum Hs-CRP and plasma D-dimer （r = 0.49, P 〈 0.01）, serum AA and plasma D-dimer （r = 0.38, P 〈 0.01）. Further more
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2014年第7期473-476,共4页
Chinese Journal of Dermatology
关键词
荨麻疹
血液凝固
急性时相反应
Urticaria
Blood coagulation
Acute-phase response
