摘要
目的探究药物性肝损伤的临床特点及相关药物分析。方法对2010年1月—2016年1月该院收治的药物性肝损伤患者资料进行研究,通过回顾性分析方式对92例药物性肝损伤患者的一般资料、用药情况、表现、相关性药物等特点进行总结。结果在初发症状中,68例患者表现为乏力,60例患者出现纳差,58例患者出现尿黄,只有15例患者表现为肝功能异常。中药导致药物性肝损伤的几率最高,约占43.5%,抗结核类药物其次,占10.9%,抗肿瘤类药物、精神类药物、抗菌类药物、解热镇痛类药物分别占6.5%。结论中年女性是药物性肝损伤患者的易发群体,中药则是导致肝损伤的主要药物类型,其中,肝细胞型损伤为主,患者预后情况良好。
Objective To study the analysis of clinical features and related drugs of 92 cases of patients with Drug-induced liver injury. Methods The patients with drug-induced liver injury admitted and treated in our hospital from January 2010 to January 2016 were selected and the general data, medication, manifestations and related drugs of the 92 cases were summarized by the retrospectively analysis method. Results 68 cases were weak, 60 cases were with poor appetite, 58 cases were with yellow urine and only 15 cases were with liver function abnormality, and the probability of drug-induced liver injury caused by the TCM is the highest, accounting for 43.5%, and the anti-tuberculosis drugs were the second, accounting for10.9%, and the antineoplastic drugs, psychotropic drugs, antibacterial drugs, antipyretic analgesics respectively accounted for 6.5%. Conclusion The middle-aged females are the susceptible population with drug-induced liver injury, and the TCM is the main drug type of liver injury, and the hepatocellular injury is the main and the prognosis of patients is good.
出处
《中外医疗》
2017年第15期121-122,125,共3页
China & Foreign Medical Treatment
关键词
药物性肝损伤
用药情况
临床特点
预后
Drug-induced liver injury
Medication
Clinical features
Prognosis
