摘要
目的介绍药物性肝损伤数据库LiverTox的内容与特点，并对其中收录的37种草药制剂进行摘录和分析。方法首先，介绍LiverTox数据库的来源和主要内容，包括药物性肝损伤的临床特征分型、病情程度分级和因果关系评价量表等内容；其次，通过阅读药物信息，详细摘录LiverTox数据库在“草药与膳食补充剂”项下收录的37种中草药制剂的药品名称、基源／来源、功效、成分组成、肝损伤类型及表现等信息，并进行初步统计分析；最后，与国内对于中草药肝损伤的现有认识进行比较分析。结果LiverTox数据库是开放获取的、信息丰富的药物性肝损伤数据库，提供了关于诊断、分型、因果关系分析和治疗的实用信息。其收录的37个草药制剂中，28个存在肝损伤风险，最常见的前3位治疗目的为减肥、治疗关节炎和便秘，不同病例发生肝毒性的潜伏期长短不一（4周至6个月）。与国内现有认识相比，LiverTox数据库收录的具有肝毒性草药制剂的品种和适应证有所不同，许多国内公认的肝毒性中草药并未被收载。结论LiverTox数据库简洁实用，但其收录的草药制剂与国内现有认识存在一定差距。
Objective To investigate the contents and features of drug-induced liver injury （DILI） database called LiverTox, as well as 37 herbal preparations included in this database. Methods Firstly, the source and contents of LiverTox were briefly introduced, including the clinical features, types, severity, and causality assessment scale of DILL Secondly, detailed information of 37 herbal preparations included in the class of ＂Herbals and Dietary Supplements＂ were extracted, including drug name, origin, efficacy, constituents, type of liver injury, and manifestations, to perform a preliminary statistical analysis. Finally, a comparative analysis was performed between such information and current knowledge of Chinese herbal medicine-induced liver injury in China. Results LiverTox was a DILI database with open access and rich information and provided practical information on treatment, typing, causality assessment, and treatment. Among the 37 herbal preparations, 28 had the risk of liver injury. The most common indication was weight loss, followed by arthritis and constipation. The latency of hepatotoxicity ranged from 4 weeks to 6 months. Compared with the current knowledge in China, there were differences in the varieties and indications for herbal preparations with hepatotoxicity included in LiverTox, and many herbals with acknowledged hepatotoxicity in China were not included. Conclusion LiverTox database is concise and practical, but there are certain differences between the herbal preparations included in this database and current knowledge in China.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2016年第11期817-823,共7页
Chinese Journal of Hepatology
基金
首都卫生发展科研专项重点攻关项目（首发2011-2008-01）
北京市中医管理局中西医结合研究项目（2014-ZYJ14）
首都医科大学附属北京世纪坛医院中青年学科骨干培养专项（院国青2015-QB04）
关键词
中草药
草药提取物
中草药制剂
药物性肝损伤
肝毒性
Chinese herb
Herbal extracts
Herbal preparations
Drug-induced liver injury
Liver toxicity
