摘要
目的对呼吸内科住院患者抗生素临床用药情况及耐药性进行分析,为抗生素使用的合理性提供方案支持。方法随机选取医院2015年11月-2017年1月接诊并住院治疗的呼吸内科患者140例患者的临床资料进行回顾性分析,并通过药房的软件系统及SPSS软件对患者抗生素药物使用情况进行分析,并对致病菌的耐药性进行探究。结果通过分析发现呼吸内科患者100%使用抗生素,其中单一用药率为45.7%,二联用药率为44.3%,三联用药率为10.0%;药物的使用频率:半合成青霉素类为38.6%、氟喹诺酮类为28.6%,大环内酯类药物为18.5%;进行细菌培养与药敏试验患者占总数的75.8%,培养与试验结果显示,在该组呼吸内科患者中病原菌主要是肺炎克雷伯菌(45.7%)、铜绿假单胞菌(34.5%)、大肠埃希菌(12.6%)和鲍曼不动杆菌(7.2%),肺炎克雷伯菌对半合成青霉素类、喹诺酮类药物及大环内酯类药物均表现出不同程度的耐药性,鲍曼不动杆菌对抗生素药物存在广泛的耐药性,铜绿假单胞菌及大肠埃希菌均对青霉素类和头孢类药物耐药性较高。结论对于呼吸内科患者,应加强抗生素药物的使用管理,同时加强对细菌的培养和药敏试验,分析其耐药性,完善抗生素药物使用的合理性。
Objective The clinical usage of antibiotics and drug resistance of patients hospitalized in respiratory de- partment were analyzed,which provided reasonable scheme support for further use of antibiotics. Methods Randomized selec- tion of clinical data from 140 patients who received hospital admissions and were hospitalized since November 2015 were retro- spectively analyzed; the use of antibiotics in patients with drugs were analyzed through the pharmacy software system and SPSS software and the resistance of pathogens were explored. In our hospital admitted to our hospital and treated in our hospital in 140 cases of patients in Department of respiratory medicine research and clinical data of patients were retrospectively through the analysis, and software system of pharmacy and SPSS software usage of antibiotics were analyzed, and the drug resistance of pathogenic bacteria to explore. Results The analysis showed that the use of antibiotics in patients with respiratory medicine is 100% ,in which a single medication rate was 45.7% ,two drug rate was 44.3% ,the triple therapy rate was 10.0%. the fre- quency of use more drugs are 38.6% for semi synthetic penicillins, 28.6% for fluoroquinolones and 18.5% for macrolides; bacterial culture and susceptibility testing patients accounted for 75.8% of the total. The results of culture and test showed that the pathogens were mainly Klebsiella pneumoniae （45.7%）, Pseudomonas aeruginosa （34.5%）, Escherichia coli （ 12.6% ） and Acinetobacter baumannii （7.2%）. These fungi showed antibiotic resistance to antibiotics, and KlebsieUa pneumoniae showed different degrees of resistance to semi-synthetic penicillins, quinolones and maerolides. Acinetobaeter baumannii has a wide range of antibiotic resistance to antibiotics;pseudomonas aeruginosa and Escherichia coli are more resistant to penieillins and cephalosporins. Condusion For the patients in department of respiratory medicine, the management in using antibiotics should be strengthened, while strengthening the bact
出处
《临床合理用药杂志》
2017年第17期1-3,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
呼吸内科
抗生素
耐药性
合理性
Respiratory medicine
Antibiotics
Drug resistance
Rationality
