摘要
目的:分析临床药学干预对呼吸内科合理使用抗生素的影响。方法:选取2021年1-12月东营胜利胜东医院呼吸内科收治的应用抗生素治疗的患者260例为研究对象。以入院时间为分组依据,将研究对象分为常规组与干预组,各130例。常规组入院时间2021年1-6月,接受常规用药指导;干预组入院时间2021年7-12月,接受临床药学干预。比较两组患者炎性因子水平[超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]、不合理用药发生情况、用药指标及不良反应发生率。结果:治疗后,两组患者hs-CRP、IL-6、TNF-α水平均降低,干预组低于常规组,差异有统计学意义(P<0.05);干预组不合理用药发生率低于常规组,差异有统计学意义(P<0.05);干预组用药时间短于常规组,用药费用、药物利用指数低于常规组,差异有统计学意义(P<0.05);干预组的不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论:临床药学干预可以对呼吸内科合理使用抗生素起到促进作用,降低患者炎性因子水平、不合理用药发生率及不良反应发生率,改善用药指标。
Objective:To analyze the influence of clinical pharmaceutical intervention on rational use of antibiotics in respiratory medicine.Methods:The study included 260 patients treated with antibiotics in the department of respiratory of Dongying Shengli Shengdong Hospital from January to December 2021.According to the time of admission,the subjects were divided into routine group and intervention group,130 cases in each group.The routine group was admitted to hospital from January to June 2021,and received the guidance of routine medication.The intervention group was admitted to hospital from July to December 2021 and received clinical pharmaceutical intervention.The levels of inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)],irrational drug use,drug indexes and incidence of adverse reactions were compared between the two groups.Results:After treatment,the levels of hs-CRP,IL-6 and TNF-αwere decreased in 2 groups,and the intervention group was lower than the routine group,with statistical significance(P<0.05).The incidence of irrational drug use in intervention group was lower than that in routine group,and the difference was statistically significant(P<0.05).The duration of medication in the intervention group was shorter than that in the routine group,and the medication cost and drug utilization index were lower than those in the routine group,with statistical significance(P<0.05).The incidence of adverse reactions in intervention group was lower than that in routine group,and the difference was statistically significant(P<0.05).Conclusion:Clinical pharmaceutical intervention can promote the rational use of antibiotics in respiratory medicine,reduce the level of inflammatory factors,the incidence of irrational drug use and adverse reactions,and improve drug use indexes.
作者
刘丽华
Liu Li-hua(Dongying Shengli Shengdong Hospital,Dongying 257000,Shandong Province,China)
出处
《中外医药研究》
2022年第13期9-11,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
临床药学干预
抗生素
合理用药
炎性因子
Clinical pharmaceutical intervention
Antibiotics
Rational drug use
Inflammatory factor
