高危妊娠患者血常规及凝血参数分析被引量：2

Analysis of routine blood and coagulation tests in high-risk pregnancy patients

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摘要目的:探讨临产高危妊娠患者血常规和凝血指标与病情的关系。方法:回顾性分析2015年1月至2016年3月本院收治的临产高危妊娠孕妇203例,参照上海市高危妊娠评分标准,分为轻度组62例,中度组76例,重度组65例;46例正常妊娠妇女(正常妊娠组)及51例未孕健康女性(未孕组)作为正常对照。检测血常规及血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(D-D)含量,并进行比较分析。结果:各妊娠组血红蛋白(HGB)、红细胞压积(Hct)、血小板(PLT)值较未孕组均显著下降,而红细胞分布宽度(RDW)显著增加(P<0.01),且重度组HGB、Hct均显著低于其他妊娠组(P<0.01)。各妊娠组红细胞平均体积(MCV)值与未孕组比较差异无统计学意义(P>0.05)。除重度组外其他妊娠组PT、APTT、TT值比未孕组均显著缩短(P<0.01或P<0.05)。各妊娠组FIB和D-D均显著高于未孕组(P<0.01),其中重度组PT、APTT、TT、D-D含量明显高于其他妊娠组(P<0.01),而FIB含量明显低于其他妊娠组(P<0.01)。结论:高危妊娠患者病情越严重,血常规及凝血各参数改变越明显,尤其是重度高危妊娠组。围产期血常规和凝血功能的监测可以为临床干预防控提供实验依据。 Objective： To explore the changes of routine blood and coagulation tests in 203 high-risk preg-nancy patients. Methods： The results were based on a retrospective analysis of 203 high-risk pregnancy cases in the First Affiliated Hospital of Wenzhou Medical University from 2015.1 to 2016.3. Routine blood and coagula-tion tests were detected by Sysmex XE-2100 and STAGO analyzer respectively. 203 high-risk pregnancy cases were divided into three groups： mild group （62 cases）, medium group （76 cases） and severe group （65 cases）. Compare the results with 46 normal pregnancy patients and 51 non-pregnant cases. Results： It showed a remark-able decline in HGB, Hct, PLT of all pregnancy groups compared with non-pregnant women, whereas significant increase was in RDW （P〈0.01）. There＆#39;re no significant difference in MCV between all groups （P〉0.05）. Com-pared with non-pregnant women, PT, APTT, TT showed a remarkable decline in all pregnancy groups except se-vere group （P〈0.05 or P〈0.01）. Fibrinogen （FIB） and D-D showed significant increase over non-pregnant women （P〈0.01）. And PT, APTT, TT, D-D in severe group showed significant increase over the other pregnancy groups （P〈0.01）, FIB showed the exact contrary （P〈0.01）. Conclusion： There＆#39;re more obvious changes of routine blood and coagulation tests in pregnancy cases especially in severe group. Routine blood and coagulation tests were very important for high-risk pregnancy patients.