摘要
目的探讨D二聚体和凝血4项检测在孕妇产前检查中的临床价值,提高妊娠高血压综合征孕妇分娩的安全性。方法 2011年8月～2012年5月,收集正常晚期妊娠妇女50例(晚孕正常组)、晚期妊娠合并妊娠高血压综合征妇女50例(晚孕妊高征组)和门诊体检非妊娠健康妇女50例(对照组),检测D-二聚体、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)。结果晚孕妊高征组血清D-二聚体水平最高,对照组最低,差异有统计学意义(P<0.05)。晚孕妊高征组PT和APTT水平最低,FIB水平最高,对照组PT和APTT水平最高,FIB水平最低,3组之间差异有统计学意义(P<0.05);3组间TT水平比较,差异无统计学意义(P>0.05)。结论正常妊娠妇女及妊娠高血压综合征妇女血液均处于高凝状态,产前检测D二聚体和凝血4项水平,有助于防止孕妇在分娩过程中发生血栓性疾病或弥漫性血管内凝血,减少产科意外的发生,可以作为产前筛查的主要指标。
Objective To investigate D-Dimer and cruor detection in antenatal examination for pregnant women,and improve the safety of pregnancy-induced hypertension pregnant woman.Methods From August 2011 to May 2012,researchers collected 50 cases of normal late pregnancy women（late pregnancy normal group）,50 cases of late pregnancy with pregnancy-induced hypertension women（late pregnancy with pregnancy-induced hypertension group） and 50 cases of non pregnancy healthy women（control group）,detected d-dimer,prothrombin time（PT）,activated part thromboplastin time（APTT）,thrombin time（TT） and fibrinogen（FIB）.Results The D-Dimer level of late pregnancy with pregnancy-induced hypertension group is the highest,and which of the control group is minimum,the differences indicated statistical significance（P〈0.05）.The PT and APTT level of late pregnancy with pregnancy-induced hypertension group is the minimum,and FIB level is the highest;The late pregnancy normal group is in the second place;and the APTT and PT of the control group is highest,and its＇ FIB level is minimum,comparing the three groups,the differences indicated statistical significance（P〈0.05）.Comparing the TT result of the three groups,the difference didn＇t indicate statistically significant（P〈0.05）.Conclusion Normal pregnancy women and pregnancy-induced hypertension women are at a high cruor state,Detection D dimer and blood coagulation in antenatal examination,can help to prevent thrombosis disease or diffuse intravascular coagulation in labor process,and reduce maternity accident,which can be used as the main indexes of prenatal screening.
出处
《四川医学》
CAS
2013年第2期284-286,共3页
Sichuan Medical Journal
