摘要
目的探讨卵巢癌组织中Yes-相关蛋白(YAP)和p73的表达及其意义。方法选取2013年1月至2016年6月在我院治疗的卵巢癌患者81例(病例组),同时选取卵巢良性肿瘤患者70例作为对照组,检测两组患者的YAP和p73蛋白表达。结果病例组患者的YAP和p73蛋白阳性表达率分别为60.49%和67.90%,明显高于对照组的11.43%和30.00%,差异均有统计学意义(P<0.05);病例组Ⅲ~Ⅳ期患者的YAP蛋白和p73蛋白阳性率为79.49%和82.05%,明显高于Ⅰ~Ⅱ期的42.86%和54.76%,差异均有统计学意义(P<0.05);病例组病理分级G3患者YAP蛋白和p73蛋白阳性率为71.67%和80.00%,明显高于G1和G2级的28.57%和33.33%,差异均有统计学意义(P<0.05);淋巴结转移患者的p73蛋白阳性率为86.96%,明显高于无淋巴结转移的60.34%,差异均有统计学意义(P<0.05)。结论卵巢癌组织YAP和p73蛋白表达增强,可能参与了卵巢癌的发生发展,其中p73与卵巢癌淋巴转移有一定关系。
Objective To investigate the expression and significance of Yes-associated protein （YAP） and p73 in ovarian cancer tissue. Methods From January 2013 to June 2016, a total of 81 patients with ovarian cancer （case group） in our hospital from January 2013 to June 2016 were selected. At the same time, 70 cases of ovarian benign tu-mor patients were enrolled as the control group. The expression of YAP and p73 protein were detected between the two groups. Results The positive expression rates of YAP and p73 protein in case group were respectively 60.49% and 67.90%, which were significantly higher than 11.43%and 30.00%in the control group （P〈0.05）. The positive rates of YAP protein and p73 protein in stageⅢandⅣwere 79.49%and 82.05%, which were significantly higher than 42.86%and 54.76%in the stageⅠ~Ⅱ, with statistically significant difference （P〈0.05）. The positive rates of YAP protein and p73 protein were 71.67%and 80.00%in pathological grading G3 patients, which were significantly higher than 28.57%and 33.33%in pathological grading G1 and G2 pateints （P〈0.05）. The positive rate of p73 protein in patients with lymph node metastasis was 86.96%, which was significantly higher than 60.34% in patients without lymph node metastasis, with statistically significant difference （P〈0.05）. Conclusion YAP and p73 protein expression in ovarian cancer tissue are enhanced, which may be involved in the occurrence and development of ovarian cancer. p73 is related to lymph node metastasis of ovarian cancer.
出处
《海南医学》
CAS
2017年第10期1560-1562,共3页
Hainan Medical Journal
基金
湖北省自然科学基金(编号:2014FFB04510)
关键词
卵巢癌
Yes-相关蛋白
P73蛋白
病理特征
Ovarian cancer
Yes-associated protein （YAP）
p73 protein
Pathological characteristics
