摘要
【目的】探讨卵巢浆液性癌的MDACC分级及临床病理意义。【方法】回顾性分析本院63例卵巢浆液性癌患者的病理资料，对其进行MDACC分级及传统WHO分级对比，所有患者行p53蛋白免疫组化染色，总结其临床病理特点并比较两种分级的优缺点。【方法】MDACC分级法中低级别相当于传统WHO分级法中的Ⅰ级，高级别组相当于Ⅱ级和Ⅲ级；MDACC分级中低级别组与高级别组患者的平均年龄、平均肿瘤直径、发生范围比较差异无统计学意义（P〉0．05）；MDACC分级中高级别组的癌症患者临床分期更高，无病生存时间及生存时间明显短于低级别组，5年生存例数少于低级别组，p53蛋白突变型表达更多，差异均具有统计学意义（P〈0．05）。【结论】MDACC分级与分子生物学表型及发病学说有非常好的契合，简便易掌握，且对预后有一定的指导意义。
[Objective]To investigate the MDACC classification of ovarian serous carcinoma and its clinical pathological significance.[Methods]Pathological data of 63 cases with ovarian serous carcinoma patients in our hospital were retrospectively analyzed, comparison of MDACC grading and traditional WHO classification were conducted. P53 immunohistochemical staining was performed in all patients, and their clinicopathological features were summarized and the advantages and disadvantages of the two grades were compared.[Results] The low grade level of MDACC classification is equivalent to the Ⅰ classification of traditional WHO, the high grade is equivalent to grade Ⅱ and Ⅲ ; In MDACC grading, the average age,the mean tumor diameter and the range of occurrence showed no difference of statistical significance in the low level group and the senior group of patients（ P 〉0.05）.In MDACC grading, clinical stage of cancer patients of high level group was higher, no disease survival duration and survival time was significantly shorter than those in the low grade group, and 5-year survival of patients was less than the number of low-level group, with more p53 mutant expression, the difference has statistical significance （ P 〈0.05）.[Conclusion]MDACC classification has a very good fit with molecular biological phenotype and pathogenesis theory, it is simple and easy to grasp,and has a certain guiding significance for the prognosis.
出处
《医学临床研究》
CAS
2016年第3期507-509,共3页
Journal of Clinical Research
