摘要
目的观察急性心肌梗死患者肺炎衣原体感染情况,探讨肺炎衣原体感染与急性心肌梗死发生的关系。方法选取2015年1月-2016年1月医院收治的急性心肌梗死患者124例为心梗组,同时选择健康体检者120名为对照组,检测两组研究者血清肺炎衣原体IgG抗体、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、可溶性血管细胞黏附分子-1(sVCAM-1)和超敏C-反应蛋白(hs-CRP)水平,采用logistic回归分析急性心肌梗死的影响因素。结果心梗组肺炎衣原体感染阳性率和浓度分别为60.5%和(64.17±15.62)RU,均明显高于对照组24.2%和(17.89±8.56)RU,差异有统计学意义(P<0.05);多元logistic回归分析显示,低密度脂蛋白胆固醇和肺炎衣原体感染是影响急性心肌梗死发生的独立危险因素,差异有统计学意义(P<0.05);心梗组肺炎衣原体抗体阳性者血清IL-6、IL-18、VCAM-1和hs-CRP水平分别为(75.13±15.27)pg/ml、(52.28±14.32)pg/ml、(38.43±7.81)nmol/L和(21.33±9.87)mg/L,明显高于抗体阴性者(24.45±6.72)pg/ml、(25.63±7.35)pg/ml、(5.43±2.17)nmol/L和(2.05±1.02)mg/L差异有统计学意义(P<0.05)。结论肺炎衣原体感染是急性心肌梗死患者发生的独立危险因素之一,其可能通过炎症反应,参与急性心肌梗死的病理过程。
OBJECTIVE To observe the infection of Chlamydia pneumoniae infection in acute myocardial infarction patients,and discuss the correlation between C.pneumoniae infection and acute myocardial infarction.METHODS A total of 124 patients with acute myocardial infarction admitted to our hospital from Jan.2015 to Jan.2016 were selected as myocardial infarction group,and 120 healthy persons were selected as control group.The serum C.pneumoniae IgG antibody,interleukin 6（IL-6）,interleukin-18（IL-18）,soluble vascular cell adhesion molecule-1 （sVCAM 1） and hypersensitive C-reactive protein （hs-CRP） of the two groups were detected.The logistic regression analysis was used for analyzing factors of acute myocardial infarction.RESULTS The positive rate and level of C.pneumoniae IgG antibody in acute myocardial infarction group were 60.5% and （64.17± 15.62）RU,which were significantly higher than those in control group with 24.2% and （17.89±8.56） RU （P〈0.05）.The multivariable logistic regression analysis showed that low density lipoprotein cholesterol and C.pneumoniae infection were independent risk factors for the occurrence of acute myocardial infarction,and the difference was significant （P〈0.05）.The levels of IL-6,IL-18,VCAM-1 and hs-CRP in antibody positive group vere （75.13±15.27）pg/ml,（52.28±14.32） pg/ml,（38.43±7.81） nmol/L and （21.33±9.87） mg/L,which were significantly higher than those in antibody negative group with （24.45±6.72） pg/ml,（25.63±7.35） pg/ml,（5.43±2.17） nmol/L and （2.05±1.02） mg/l（P〈0.05）,respectively.CONCLUSION C.pneumoniae infection is one of the independent risk factors for acute myocardial infarction,which may involve in pathological process of acute myocardial infarction through inflammation.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第11期2480-2483,共4页
Chinese Journal of Nosocomiology
关键词
肺炎衣原体感染
急性心肌梗死
相关性
Chlamydia pneumonia infection
Acute myocardial infarction
Correlation
