摘要
目的研究不稳定心绞痛患者肺炎衣原体抗体IgG和IgM表达,分析感染因素。方法选取2014年8月-2015年8月医院接诊40例不稳定心绞痛患者为观察组,另选取同期健康体检者40名为对照组,检测两组受试者TNF-α、CRP、tPA、PAI-1及CpnIgG、CpnIgM表达,观察两组相关资料比较,TNF-α、CRP、tPA、PAI-1及Cpn抗体检测结果,肺炎衣原体抗体IgG与各监测指标水平比较。结果两组tPA水平无明显差异,观察组TNF-α(2.84±0.26)μg/L、CRP(6.82±1.10)mg/L、PAI-1(0.82±0.12)AU/ml均大于对照组(0.60±0.28)μg/L、(2.47±0.70)mg/L、(0.45±0.14)AU/ml,差异有统计学意义(P<0.05);两组Cpn-IgM阳性率无明显差异,Cpn-IgG阳性率差异有统计学意义(P<0.05),两组HDL-C水平无明显差异;阳性组TC、TG、LDL-C、PAI-1、CRP、TNF-α(4.92±0.89、1.87±0.59、2.56±0.68)mmol/L、(0.79±0.24)AU/ml、(5.26±1.30)mg/L、(2.19±0.68)μg/L均大于阴性组(4.22±0.75、1.18±0.31、2.19±0.56)mmol/L、(0.38±0.11)AU/ml、(2.70±0.86)mg/L、(1.06±0.34)μg/L(P<0.05),tPA活性(0.43±0.05)IU/ml小于阴性组(0.52±0.07)IU/ml,差异有统计学意义(P<0.05)。结论肺炎衣原体抗体IgG与不稳定心绞痛有密切的关系,会促进炎症因子的释放,诱导CRP、TNF-α产生,干扰血浆脂质代谢,从而导致患者不稳定心绞痛病发。
OBJECTIVE To study the expression of Chlamydia pneumoniae antibodies IgG and IgM in patients with unstable angina and analyze the related factors for infection.METHODS Totally 40 patients with untable angina who were treated in the hospital from Aug 2014 to Aug 2015 were chosen as the observation group,meanwhile,40 healthy people who received physical examination were set as the control group.The expression of TNF-α,CRP,tPA,and PAI-1,as well as CpnIgG and CpnIgM in the two groups of participants were detected,the related data was observed and compared between the two groups,the result of detection of TNF-α,CRP,tPA,PAI-1,and Cpn antibodies was observed,and the levels of C.pneumoniae antibody IgG and the monitoring indexes were compared.RESULTS There was no significant difference in the tPA level between the two groups.The levels of TNF-α,CRP,and PAI-1of the observation group were respectively（2.84±0.26）μg/L,（6.82±1.10）mg/L,and（0.82±0.12）AU/ml,higher than（0.60±0.28）μg/L,（2.47±0.70）mg/L,and（0.45±0.14）AU/ml of the control group,and there was significant difference（P〈0.05）.There was no significant difference in the positive rate of Cpn-IgM between the two groups;there was significant difference in the positive rate of Cpn-IgG（P〈0.05）.There was no significant difference in the HDL-C level between the two groups.The levels of TC,TG,LDL-C,PAI-1,CRP,and TNF-αof the positive group were respectively（4.92±0.89,1.87±0.59,2.56±0.68）mmol/L,（0.79±0.24）AU/ml,（5.26±1.30）mg/L,and（2.19±0.68）μg/L,higher than（4.22±0.75,1.18±0.31,2.19±0.56）mmol/L,（0.38±0.11）AU/ml,（2.70±0.86）mg/L,and（1.06±0.34）μg/L of the negative group.The tPA activity of the positive group was（0.43±0.05）IU/ml,less than（0.52±0.07）IU/ml of the negative group,and there was significant difference（P〈0.05）.CONCLUSIONThe C.pneumoniae antibody IgG is closely associated with the unstable angina,it may promote the release of inflammatory factors,induce the emergence of
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第6期1244-1246,共3页
Chinese Journal of Nosocomiology
基金
武汉市科技计划基金资助项目(WX16E07)
