摘要
目的:探讨心肾综合征(CRS)预后的影响因素。方法:收集104例CRS患者的临床资料,并对其进行2a随访,根据随访期间是否发生心血管不良事件或心源性猝死分为预后较好组(n=52)和预后不良组(n=48),对两组心血管不良事件或心源性猝死发生情况及心肾相关指标进行比较,采用Cox比例风险回归筛选CRS预后的独立影响因素。结果:与预后较好组比较,预后不良组血浆尿素、肌酐、尿酸、胱抑素-C水平均升高,左室射血分数、肾小球滤过率降低,低NT-pro BNP水平的患者比例较低(P<0.05)。其中左室射血分数[β=0.911,RR(95%CI)=2.487(1.293~4.782)]和血浆肌酐水平[β=1.034,RR(95%CI)=2.813(1.464~5.404)]是CRS预后的独立危险因素。结论:左室射血分数和血浆肌酐水平是预测CRS预后的良好指标。
Aim： To explore the prognosis influencing factors of cardiorenal syndrome（ CRS）. Methods： A total of104 CRS patients were selected. According to the occurrence of adverse cardiovascular events or sudden cardiac death during 2 years follow-up,the patients were allocated into two groups： good prognosis group（ n = 52） and poor prognosis group（ n = 48）. The cases developed adverse cardiovascular events or sudden cardiac death and the indexes of heart and kidney of the two groups were compared statistically,and Cox regression model was established to identify independent influencing factors of CRS prognosis. Results： Compared with those of the good prognosis group,the plasma levels of urea,creatinine,uric acid and cystatin-C in poor prognosis group were higher,and left ventricular ejection fraction（ LVEF） and glomerular filtration rate were lower,the proportation of the patients with low plasm level of NT-pro BNP was lower（ P 〈 0. 05）.LVEF[β = 0. 911,RR（ 95% CI） = 2. 487（ 1. 293-4. 782） ] and serum creatinine[β = 1. 034,RR（ 95% CI） = 2. 813（ 1. 464-5. 404） ]were the independent risk factors of CRS. Conclusion： LVEF and serum creatinine are good indexes to predict the prognosis of CRS.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2017年第3期306-309,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省教育厅科技攻关项目162102310200
关键词
心肾综合征
影响因素
预后
cardiorenal syndrome
influencing factor
prognosis
