摘要
目的探讨慢性心力衰竭患者肿瘤抗原CA125（简称CA125）含量与患者心功能之间的关系。方法采用免疫酶联ELISA法测定62例CHF患者血清CA125水平,并对20例NYHAⅣ级患者治疗前后血清CA125的水平进行比较,用心脏彩色超声心动仪测定左心室功能。结果①血清CA125水平随着心衰程度的加重而显著升高（P≤0.05）,A组即NYHAⅠ、Ⅱ较对照组高（P≤0.05）,而B组即NYHAⅢ、Ⅳ较之A组及对照组,NYHAⅢ、Ⅳ级患者的CA125血清水平显著上升（P≤0.05）,且与左室射血分数（LVEF）呈负相关（r=-0.81,P≤0.01）。②NYHAⅣ级患者治疗前后血清CA125均值间差别有显著性意义（P≤0.05）。结论血清CA125水平能预测CHF的有无及严重程度,可以作为心功能的监测指标。
Obsjactive To invstigate the relationship betreen the serum level of CA125 and chronic heart faluer（CHF）.Methods We measured the serum level of cancer antigen 125（CA125） and chronic heart falure by enzyme linked immunosorbent assay（ELISA） in patients with mild to severe CHF（n=62） ,and compared the levels of CA125 of NYHA Ⅳ patients（n=20） before and after medical treatment Clored Doppler echocardiography was performed to measure the left ventricular function. Rrsult ①The mean value of serum CA125 increased with increment of NYHA classificasion（P≤0.05）,which was nagatively correlated with left ventricular ejection fraction（P≤0.01）.②In 20 NYHA Ⅳ patients after aggresive medical treatment,the serum level of CA125 decreased from 178.5±113.2 to26.8±14.1UI/ml（P≤0.05）.Conclusion CA125 seems to be related with the presence and severity of CHF,which shows the significanct changes in response to medical therapy
出处
《中国中医药现代远程教育》
2009年第12期118-119,共2页
Chinese Medicine Modern Distance Education of China
