摘要
甲状旁腺激素是由甲状旁腺主细胞合成并分泌的多肽类分子,是维持机体钙磷代谢平衡的一种重要的调钙激素,可促进骨形成与骨吸收,加快骨转换。目前临床上甲状旁腺激素主要用于防治妇女绝经期骨质疏松症和降低骨折的发生率。甲状旁腺激素通过刺激成骨细胞、破骨细胞、牙周膜细胞、成牙骨质细胞等的增殖和分化来促进牙周组织改建和愈合,有效地控制牙槽骨的丧失,加速正畸牙的移动,以及促进种植体与牙槽骨的骨结合。本文就近年来甲状旁腺激素对牙周组织再生与改建的相关临床和基础研究作一综述,旨在为甲状旁腺激素在牙周组织的应用与研究提供参考。
Parathyroid hormone（PTH） is a polypeptide molecule synthesized and secreted by the chief cell of parathyroid glands and is a vital calcium-regulating hormone, which could maintain the balance of calcium and phosphorus metabolism in vivo. PTH could promote the regeneration and absorption of bone and accelerate bone turnover. Nowadays, PTH is used for the prevention and treatment of osteoporosis in menstruating women and could decrease the rate of fracture in clinic. Moreover, researchers found that PTH could promote the concrescence and remodeling of periodontal tissue, control the absorption of alveolar bone, accelerate orthodontic tooth movement, and improve the osseointegration of dental implant by stimulating the proliferation and differentiation of osteoblast, osteoclast, periodontal ligament cell, and cementoblast. This review focuses on the progress of PTH in the regeneration and remodeling of periodontal tissue in recent years.
出处
《国际口腔医学杂志》
CAS
CSCD
北大核心
2017年第4期466-470,共5页
International Journal of Stomatology
基金
国家自然科学基金(81460101)~~
关键词
甲状旁腺激素
牙周组织
骨再生
牙槽骨
parathyroid hormone
periodontal tissue
bone regeneration
alveolar bone
