摘要
目的:探讨家养宠物暴露对非哮喘儿童肺功能的影响,为预防儿童肺功能损伤提供科学依据。方法:采用横断面调查的方法,在辽宁省7个城市的24个行政区,整群随机抽取1~2所初中和小学,进行ATS问卷调查,并采用便携式肺功能呼吸仪测定肺功能,包括第1 s用力呼气量(FEV1),用力肺活量(FVC),最大呼气中期流量(MMEF)和呼气峰流量(PEF)。结果:本研究共调查了7~14岁的非哮喘儿童青少年6 280例,其中男孩3 107例,占49.47%。儿童肺功能的FVC、FEV1、PEF和MMEF指标平均分别为(2.63±0.75)L、(2.47±0.70)L、(4.80±1.42)L/s和(3.37±1.05)L/s。在调整了性别、年龄、BMI等混杂因素后,在出生后前两年曾暴露于家养宠物与FVC肺功能指标损伤显著相关(a OR=1.30;95%CI:1.01~1.67),且目前暴露于家养宠物与FVC(a OR=1.32;95%CI:1.09~1.61)、FEV1(a OR=1.47;95%CI:1.19~1.83)、PEF(a OR=1.48;95%CI:1.16~1.88)和MMEF(a OR=1.35;95%CI:1.09~1.66)4个肺功能指标损伤均显著相关。而出生前曾暴露于家养宠物与肺损伤各指标均不相关。结论:家养宠物对非哮喘儿童的肺功能有损害作用,可降低FVC、FEV1、PEF和MMEF等指标。
Objective To investigate the association between pet ownership and lung function in children without asthma, and to provide scientific basis for the improvement of lung function in children. Methods Data was drawn from the cross-sectional study, the clusters were randomly selected from 1 to 2 junior middle schools and primary schools in 24 administrative regions of seven cities in Liaoning Province. The ATS questionnaire survey was performed, and lung function including the forced expiratory volume in 1 second （FEV1）, forced vital capacity （FVC）, maximal mid-expiratory flow （MMEF） and peak expiratory flow （PEF） was measured by utilizing portable electronic spirometers. Results In this study, about 6280 children without asthma aged 7 ± 14 years were enrolled, 49.47 % of the children was male. The average lung function of FVC, FEV1, PEF and MMEF was （2.63±0.75） L, （2.47 ± 0.70） L, （4.80 ±1.42） L/s and （3.37±1.05） L/s, respectively. By adjusting confounding fac- tors, we found pet ownership in the first 2 years of life was significantly associated with the predicted lung function impairment of FVC 〈 85% （aOR = 1.30; 95% CI： 1.01 - 1.67 ） ; current pet ownership was significantly associated with the predicted lung function impairment of FVC 〈 85% （aOR = 1.32; 95% CI： 1.09 ± 1.61 ） , the predicted FEVI 〈 85%（aOR = 1.47; 95% CI： 1.19 ± 1.83）, the predicted PEF 〈 75%（aOR = 1.48; 95% CI： 1.16 - 1.88） and the predicted MMEF 〈 75%（aOR = 1.35; 95% CI： 1.09 - 1.66）. The in utero exposure was not related to lung function impairment. Conclusion Pets ownership has damaging effects on lung function in children without asth- ma, and it reduces FVC, FEV1, PEF and MMEF in children.
出处
《实用医学杂志》
CAS
北大核心
2017年第11期1868-1872,共5页
The Journal of Practical Medicine
基金
国家自然科学基金(编号:81472936)
广东省国际合作项目(编号:2014A050503027)
关键词
宠物
肺功能
儿童
Pet
Lung function
Children
