摘要
目的:探究氯吡格雷与前列地尔联用对急性脑梗死的有效性与安全性。方法:选取2013年3月-2015年3月在笔者所在医院进行治疗的急性脑梗死患者120例,并随机分为两组。观察组60例患者进行吡格雷与前列地尔联用治疗,对照组60例患者进行阿司匹林治疗。治疗结束后对两组患者的有效性与安全性进行分析比较。结果:在治疗结束后,观察组患者NIHSS评分为(2.9±3.3)分,对照组患者NIHSS评分为(4.4±2.9)分。治疗后对照组血小板聚集率为(57.5±10.6)%;血浆Ⅷ因子相关抗原为(0.7±0.2)mg/L;白细胞介素6为(90.3±15.7)mg/L;组织型纤溶酶原激活物为(0.4±0.1)k U/L;组织型纤溶酶原激活物抑制物为(1.0±0.1)k U/L。观察组上述5项指标分别为(40.1±13.1)%、(0.5±0.2)mg/L、(65.2±14.3)mg/L、(0.6±0.1)k U/L、(0.6±0.1)k U/L,与治疗前相比差异均有统计学意义(P<0.05),治疗后两组患者指标相比差异有统计学意义(P<0.05)。两组患者均未产生脑出血、消化道出血,观察组患者出现轻度腹泻、皮疹、鼻黏膜出血、牙龈出血分别为4例(6.7%)、4例(6.7%)、2例(3.3%)、2例(3.3%)。结论:在治疗急性脑梗死时,采用氯吡格雷与前列地尔联用治疗的方法效果良好,安全性高,应在临床推广使用。
Objective： To study the efficacy and safety of Clopidogrel combined with Alprostadil on acute cerebral infarction.Method： From March 2013 to March 2015 in our hospital for treatment of acute cerebral infarction in 120 cases, and randomly divided into 2 groups.The observation group of 60 patients received Alprostadil combined with Clopidogrel, 60 patients of the control group received Aspirin therapy.The effectiveness and safety of the 2 groups of patients after the end of the treatment were analyzed and compared.Result： After the treatment, the NIHSS score of the observation group was （2.9 ± 3.3） and the NIHSS score of the control group was （4.4 ± 2.9）.After treatment, in the control group, the platelet aggregation rate was （57.5 ± 10.6）%; yon Willebrand factor related antigen for （0.7 ± 0.2）mg/L, interleukin for （90.3 ± 15.7）mg/L, tissue type plasminogen activator plasminogen activator for （0.4 ± 0.1）kU/L; tissue type plasminogen activator mitogen activated inhibitor for （1.0 ± 0.1）kU/L.The 5 indexes of the observation group were （40.1 ± 13.1）%, （0.5 ± 0.2）mg/L, （65.2 ± 14.3）mg/L, （0.6 ± 0.1）kU/L, （0.6 4-0.1）kU/L.The differences were statistically significant compared with before treatment（P〈0.05）,There were significant differences in the indexes of the 2 groups after treatment（P〈0.05）.Two groups patients without cerebral hemorrhage, gastrointestinal bleeding, in the observation group patients, mild diarrhea, rash, nasal mucosa bleeding, gingival bleeding were 4 cases（6.7%）, 4 cases（6.7%）, 2 cases（3.3%）, 2 cases（3.3%）.Conclusion： In the treatment of acute cerebral infarction, with clopidogrel combined with Alprostadil has good treatment effect, high safety, should be used in clinical practice.
出处
《中外医学研究》
2017年第17期9-11,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
