摘要
目的观察三阴性乳腺癌(TNBC)患者的体重指数(BMI)与临床结局的关系。方法收集2005年12月至2015年12月在延庆区和大兴区医院肿瘤科就诊的1 680例乳腺癌患者相关资料,筛选三阴性乳腺癌患者纳入本研究,共计105例。通过患者身高和体重计算BMI指数,根据BMI指数将患者分为BMI<25(正常/低体重组),25~29.9(超重组)和≥30(肥胖组)三组。对比观察三组患者的基础信息、临床特征、组织学分类和总生存期(OS)。结果患者平均随访期28.4±16.4个月,其中12例复发(11.4%),4例死亡(3.8%)。肥胖组患者的年龄大于其他两组(P<0.05),肥胖患者与超重患者、正常/低体重组患者的OS无显著差异;考虑绝经因素,绝经前患者的平均BMI水平显著低于绝经后患者(P<0.05);绝经后TNBC患者中,肥胖患者相比超重患者、正常/低体重组更易获得较短的OS(P<0.05)。结论肥胖是绝经后TNBC患者获得更短OS的相关因素。
Objective In this study, we evaluated the impact of obesity on clinical outcomes of Triple - negative breast cancer （TNBC） patients. Methods The data of 1,680 breast cancer patients were collected from Department of Oncology, Yanqing District and Daxing District Hospital from Dec. 2005 to Dec. 2015. The body mass index （BMI） of 105 TNBC patients was calculated with weight at the time of diagnosis and height. The patients were classified into groups with a BMI of 〈25 （normal/underweight）, 25.0 -29. 9 （ overweight） or ≥30 （ obese）. Overall survival （OS） was assessed. Results After a mean follow - up of 28.4 ± 16. 4 months, there were 12 recurrences （11.4% ） and 4 deaths （3.8%）. The mean BMI in premenopausal patients was significantly lower than in postmenopausal patients （ P 〈0.05） . The survival analyses of all the patients did not demonstrate any differences in OS in obese as compared to non - obese patients. However, we showed that obesity was associated with a poorer OS for postmenopausal TNBC patients （ P 〈0.05） . Conclusion Obesity is related to a poorer OS in postmenopausal TNBC patients.
出处
《临床和实验医学杂志》
2017年第12期1175-1177,共3页
Journal of Clinical and Experimental Medicine
基金
首都医学发展科研基金资助项目(编号2007-1049)
关键词
乳腺癌
三阴性
身体质量指数
预后
相关性
Breast cancer
Triple negative
Body mass index
Prognostic factor
Correlation
