摘要
目的探讨天津市手足口病的流行情况和病原学特征。方法收集2008-2015年国家传染病报告信息系统中报告的天津市临床诊断的手足口病病例的疫情资料,采集11 901例临床诊断手足口病的病例标本对其进行肠道病毒检测。结果 2008-2015年天津市手足口病的高发年份为2010年,发病率为229.43/10万,高发月份为6~7月份,高发年龄为1~3岁,津南区、静海区和蓟县为高发区县。重症病例发生率仅为0.15%,主要发生在6~7月份,主要病原为EV-A71,占87.00%。2008-2012年天津市手足口病的主要病原为EV-A71,分布占全部阳性病原的85.88%、43.17%、44.32%、49.24%和40.41%。2013年和2015年以CV-A6为主,分别占54.69%和41.01%,2014年以CV-A16为主占34.38%。重症病例和轻症病例的病原构成经χ~2检验,差异有统计学意义(P=0.000)。结论在手足口病高发季节前应对重点地区、重点人群进行宣传预防,以防止手足口病大范围暴发流行。
Objective To study the epidemiologic characteristics and pathogen of hand-foot-mouth disease （HFMD） in Tianjin of China. Methods HFMD data between 2008 and 2015 in Tianjin of China was collect- ed from the Information System for Disease Control and Prevention of China. A total of 11 901 HFMD samples were tested for enterovirus. Results The highest annual incidence of HFMD was 229.43/100 000 in the year of 2010. Most cases occurred in June and July with age peak at 1 to 3 years old. The highest epidemic areas in Tianjin are Jinnan, Jinghai and Jixian districts. The severe HFMD case accounted for 0.15% and mostly in June and July. The dominant pathogen is EV-A71 85.88%, 43.17%, 44.32%, 49.24% and 40.41% from 2008 to 2012. CV-A6 was the dominant pathogen in 2013 and 2015 （54.69% and 41.01%, respectively） while CV-A16 in 2014 （34.38%）. There is significant difference between severe cases and mild cases in pathogens （P=0. 000）. Conclusions Different viruses dominated the epidemics from 2008 to 2015 in Tianjin of China while the EV-A？I was the most popular virus.
作者
李佳萌
吕莉琨
李力
谭昭麟
李琳
顾新蕊
许文波
LI Jia-meng LU Li-kun LI Li TAN Zhao-lin LI Lin Gu Xin-rui XU Wen-bo(Center for Disease Control and Prevention of Tianjin City, Tianjin 300011 , China)
出处
《中国病毒病杂志》
CAS
2017年第2期129-134,共6页
Chinese Journal of Viral Diseases
关键词
手足口病
流行特征
病原学
Hand, food and mouth disease
Epidemiologic characteristics
Etiology
