摘要
目的:对加味小柴胡汤颗粒及其有效物质部位组方进行抗胃溃疡的药效研究,为其临床疗效提供科学依据,并为开发加味小柴胡汤颗粒医院制剂奠定基础。方法:构建大鼠幽门结扎型、醋酸刺激型及小鼠无水乙醇诱发胃溃疡等动物模型,以加味小柴胡汤颗粒及其有效物质部位组方作为供试药物进行试验研究。观察其对模型动物的治疗作用,以及对胃液分泌、胃酸含量、胃蛋白酶活性、超氧化物歧化酶活性(SOD)和丙二醛(MDA)含量的影响。结果:加味小柴胡汤颗粒及其有效部位组方,与空白模型组相比,均能明显降低胃溃疡指数(P<0.01)、胃液总酸度(P<0.01)和胃蛋白酶活性(P<0.05或P<0.01),提高SOD活力(P<0.05),抑制MDA升高(P<0.05)。结论:加味小柴胡汤颗粒及其有效部位组方对急、慢性胃溃疡均具有较好的药效作用,其作用机制与降低胃液总酸度及胃蛋白酶活性、提高SOD活力,抑制MDA升高等有关。
Objective： To investigate the pharmacodynamics of modified Xiaochaihutang granules （MXG） and its active ingredi- ents group （AIG） on gastric ulcer in order to provide scientific basis for the clinical effect and lay foundation for the development of re- lated hospital preparations. Methods： Gastric ulcer models induced by pyloric ligation, acetic acid and ethanol were applied to observe the curative effects of MXG and its AIG, and the effects of MXG and its AIG on gastric secretion, gastric acid content, pepsin activity, superoxide dismutase （SOD） and malondialdehyde（MDA） contents were also studied. Results： Compared to the model control group, MXG and AIG could significantly reduce the ulcer index （ P 〈 0.01 ）, total acidity （ P 〈 0.01 ）, and pepsin activity （ P 〈 0.05 or 0.01 ）, increase the SOD activity （ P 〈 0.05 ） and inhibit the increase of lipid peroxide MDA. Conclusion： MXG and AIG show better control effects on acute and chronic gastric ulcer, and the effects are related to reducing the activity of pepsin, increasing the SOD ac- tivity, inhibiting the increase of lipid peroxide MDA and so on.
作者
刘蔚
杨梦玲
陈雪剑
周爱军
陈树和
刘焱文
Liu Wei Yang Mengling Chen Xuejian! Zhou Aijun Chert Shuhe Liu Yanwen(Provincial Key Laboratory of Traditional Chinese Medicine Resources and Traditional Chinese Medicine Chemistry of Hubei University of Chinese Medicine, Wuhan 430060, China Dongguan Hospital of Traditional Chinese Medicine Hubei Provincial Hospital of TCM)
出处
《中国药师》
CAS
2017年第6期1031-1034,共4页
China Pharmacist
基金
广东省东莞市社会科技发展项目(编号:2013108101036)
关键词
加味小柴胡汤颗粒
有效部位组方
胃溃疡模型
溃疡指数
Modified Xiaochaihutang granules
Active ingredients group
Gastric ulcer model
Ulcer index
