摘要
色素上皮源性因子(PEDF)是一种丝氨酸蛋白酶抑制剂,其具有抗炎症反应、抗氧化应激、抑制新生血管生成、神经营养及神经保护等功能。越来越多的研究显示,PEDF与糖尿病性肾病(DN)密切相关,PEDF可以抑制细胞间黏附分子-1(ICAM-1)、单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和血管内皮生长因子(VEGF)等炎症因子的表达,提示其具有抗炎症反应的活性。PEDF也具有促进内皮细胞凋亡、抑制纤维化等对肾脏的保护作用。因此,PEDF有望成为DN治疗的一种新选择。
Pigment epithelium-derived factor is a member of super family of serine protease inhibitors with anti-inflammatory,anti- oxidative,anti-angiogenic,neurotrophic and neuroprotective properties. Recently,more and more studies showed that PEDF is closely associated with diabetic nephropathy （DN）. PEDF inhibits the expression of proinflammatory factors,including intercellular adhesion molecule-1 （ICAM-1）, monocyte chemoattractant protein-1 （MCP- 1 ）, Tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6） and Vascular endothelial growth tactor （VEGF）, suggesting it has anti-inflammatory effect. Moreover, PEDF could also promote endothelial cell apoptosis and prevent renal fibrosis which plays a pivotal protective role in diabetic nephropathy （DN）. Therefore, PEDF may be a promising choice for the treatment of DN.
出处
《职业与健康》
CAS
2017年第7期984-988,共5页
Occupation and Health
关键词
色素上皮衍生因子
糖尿病肾病
抗炎症反应
Pigment epithelium-derived factor
Diabetic nephropathy
Anti-inflammatory
