摘要
目的：探讨氧化应激指标、血管内皮生长因子（VEGF）与白内障的相关性。方法：选择2012年4月～2013年6月期间来我院就诊的老年性白内障患者102例为观察组，同时期健康志愿者102例作为对照组，比较两组患者房水和血清中氧化应激相关指标超氧化物歧化酶（SOD）、丙二醛（MDA）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH—Px）、过氧化脂质（LPO）及VEGF水平，并比较不同年龄患者房水中各氧化应激相关指标的差异。结果：观察组房水中MDA、CAT及VEGF水平高于对照组，SOD、GSH—Px低于对照组，差异有统计学意义（P均〈0．05）；观察组血清中MDA、LPO及VEGF水平高于对照组，SOD低于对照组，差异有统计学意义（P均〈0．05）。随着白内障患者年龄的增长，患者房水中SOD、GSH—PX水平明显下降，而MDA、VEGF水平明显升高（P均〈0．05）。结论：白内障患者房水及血清中氧化应激指标及血管内皮生长因子水平异于正常人群，且其高低与年龄相关。
Objective. To investigate the change of oxidative stress indicators and VEGF in aqueous humor and serum of patients with cataract. Methods. 102 patients with cataract from April 2012 to June 2013 were selected as observation group, and 102 healthy cases were selected as control group. The levels of oxidative stress indicators （SOD, MDA, CAT, GSH-PX, LPO） and VEGF in aqueous humor and ser- um of two groups were compared, these indicators in patients at different age were also compared. Re- sults..The levels of MDA, CAT and VEGF in aqueous of observation group were higher than those indexes of control group,but the levels of SOD and GSH-PX were lower than those indexes of control group （all P 〈0.05）. The levels of MDA, LPO and VEGF in serum of observation group were higher than those inde- xes of control group,but the levels of SOD was lower than those indexes of control group （all P〈0.05）. As aging, the levels of SOD and GSH-PX in aqueous of cataract patientson were significantly decreased, and the levels of MDA and VEGF were significantly increased （all P〈0.05）. Conclusions. The levels of oxidative stress indicators and VEGF in aqueous humor and serum of patients with cataract are decreased, And the levels are related to the age.
出处
《海南医学院学报》
CAS
2014年第3期418-420,423,共4页
Journal of Hainan Medical University
基金
四川省成都市科技资助基金资助项目(201023898)~~
