摘要
目的:通过比较激素补充治疗(HRT)和中药治疗围绝经期综合征的成本,评估HRT的经济学效益。方法:本研究基于丹麦骨质疏松预防研究(DOPS)模型,以10万名围绝经期妇女为队列,采用成本效果分析法分析一年期和五年期直接治疗成本和间接治疗成本。结果:在疗效同等的假设下,对比中药治疗组HRT组一年期可减少骨折发生例数60例,减少心血管事件发生数188例,五年期减少骨折发生例数298例,减少心血管事件发生数923例;按65%依从性计算,HRT组相比中药治疗组一年期6 631.14万元,可以节约总治疗成本7 295.21万元;五年期可以降低药费28 541.48万元,可以节约总治疗成本31 372.70万元。结论:HRT治疗相比于中药治疗产生的费用更低,且具有良好的远期获益,可以节约卫生资源,减轻患者负担,是治疗围绝经期综合征的较好治疗方案。
Objective： To compare the cost of hormone replacement therapy（HRT） and traditional Chinese medicine （TCM） in the treatment of perimenopause syndrome, and evaluate the economic benefits of HRT. Methods： Based on the Danish Osteoporosis Pre- vention Study（DOPS） model, 100 000 perimenopausal women in the cohort were seleeted to analyze direet cost and indirect cost of treatment therapy by cost-effectiveness analysis for a period of 1 year and 5 years. Results： Under the hypothesis of the same treat- ment effeet, compared with the traditional Chinese medicine treatment group and the HRT group, the treatment couht redue, e fracture in 60 eases and reduce the numher of cardiovascular events in 188 eases druing 1year; the treatment could reduce fracture in 298 cas- es and reduce the number of cardiovascular events in 923 cases during 5 years. Calculated at 65% compliance, compared with the tra- ditional Chinese medicine treatment group, the tTRT group eould reduce the cost of 66,3114 million yuan and save the total treatment cost of 72.9521 million yuan during 1 year. The treatment could reduce the cost of 285.4148 million yuan and save the total treatment cost of 313.727 million yuan during 5 years. Conclusion： Compared with traditional Chinese medicine treatment, HRT treatment had lower cost and better benefit in the long term. It could save health resources and reduce the burden of patients, which was a good treat- ment for perimenopausal syndrome.
出处
《中国卫生经济》
北大核心
2017年第1期44-48,共5页
Chinese Health Economics
关键词
激素补充治疗
围绝经期综合征
成本分析
hormone replacement therapy
perimenopause syndrome
cost analysis
