摘要
目的研究中老年妇女尿酸的变化程度对肾功能的影响。方法选取大连地区血尿酸〈7mg／dl、估算。肾小球滤过率（eGFR）≥90ml·min^-1·（1．73m^2）^-1、年龄〉45岁的中老年妇女1152名，采用2011年8月～2011年12月的数据作为基线数据、2014年7月至2014年12月的数据作为随访数据进行3年随访研究。结果对肾功能正常的中老年妇女人群进行一系列分析后结果显示，1152名受访人群3年后eGFR显著性下降：基线尿酸四分位分组最高组与最低组相比，eGFR下降至90ml·min^-1·（1．73m^2）^-1以下发生率的风险显著增高[OR=1．707，95％CI1．192～2．443，P=0．003]；继续细化研究血尿酸的变化程度对肾功能的影响，相关分析显示尿酸增高程度与eGFR下降幅度呈正相关（r=0．172，P=0．000），且线性回归分析显示血尿酸增高程度越大，eGFR下降幅度越大[β=1．562，95％CI1．050～2．075，P〈0．01]，血尿酸增高的程度是eGFR下降幅度的独立危险因素。结论基线肾功能正常的中老年妇女在轻度增高的血尿酸水平甚至在正常范围内轻度增高的血尿酸水平与估算肾小球滤过率降低相关，且血尿酸增高的程度是导致估算肾小球滤过率下降幅度的独立危险因素。
Objective To determine the impact of uric acid changes on kidney function in middle-aged and elderly women with normal renal function. Methods Serum uric acid and estimated glomerular filtration rate （ eGFR ） were studied by prospective cohort analysis in 1152 middle-aged and elderly Dalian women with serum uric acid〈7 mg/dl, estimated glomerular filtration rate（eGFR） ≥90 ml · min^-1 · （ 1.73 m^2 ）^-1 , and age〉45 years old. Results The analysis of variance （ANOVA） of clinical indices between baseline and follow-up data showed that an eGFR was decreased after three years in both middle-aged and elderly women even with normal serum urie acid. Compared with those in the lowest guartile subgroup, a significant drop of eGFR to less than 90 ml · min^-1 （ 1.73 m^2 ）^-1 ] was seen in those with the highest guartile of baseline serum uric acid group （ OR = 1. 707, 95% CI 1. 192-2. 443, P = 0. 003 ）. Furthermore, there were positive correlations between changes in the levels of serum uric acid and eGFR, and linear regression analysis showed that, as the change level of serum uric acid increased, the change level of eGFR declined （β = 1. 562, 95 % CI 1. 050-2. 075, P〈0.01 ] , and the changing degree of uric acid increase is independent risk factors refor eGFR reductions. Conclusion Reduction in eGFR level is inversely related to serum uric acid in perimem）pausal and postmenopausal women. However, our study showed that, women with serum uric acid level ranging from ncnanal, slight increase, and relatively high levels, the increasing degrees of uric acid are independent risk factors responsible for the changing degree of eGFR reduction.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2017年第5期392-397,共6页
Chinese Journal of Endocrinology and Metabolism
基金
国家科技支撑计划项目（2013BAI09813）
关键词
中老年
尿酸
估算肾小球滤过率
Middle-aged and chiefly
Uric acid
Estimated glomerular filtration rate
