摘要
目的探讨青年男性冠心病（CHD）患者危险因素及冠状动脉病变特点。方法入选2014年10月至2015年7月于天津市胸科医院心内科住院行冠状动脉造影的222例患者为研究对象,根据其年龄、检查结果分为青年CHD组（年龄≤45岁,n=82）、老年CHD组（年龄≥60岁,n=80）、青年对照组（年龄≤45岁,n=60）三组。对三组患者的一般资料及临床指标进行统计学分析,比较青年CHD组与老年CHD组的冠状动脉病变特点,采用logistic回归分析青年男性CHD患者的独立危险因素。结果青年CHD组与老年CHD组及青年对照组比较,部分基线数据及临床资料有显著统计学差异（P〈0.05）。青年男性CHD冠状动脉病变多为单支病变且多累及左冠状动脉前降支。青年CHD组Gensini积分在0~24分的比例明显多于老年CHD组（P〈0.05）,而Gensini积分〉60分的比例明显低于老年CHD组（P〈0.05）。以青年对照组为参照,logistic回归分析显示吸烟、高脂血症、高血压、糖尿病、CHD家族史为青年男性CHD患者独立危险因素。结论吸烟、高脂血症、高血压、糖尿病、CHD家族史是青年男性CHD患者的独立危险因素,青年男性CHD患者冠状动脉病变以单支病变为主且多累及前降支,病变范围、程度较老年男性轻。
Objective This objective was to investigate the risk factors of CHD and characteristics of coronary artery among the male CHD（coronary heart disease） patients under the age of 45. Methods 222 patients from 2014 October to 2015 July in the cardiology department of Tianjin Chest Hospital who underwent coronary angiography（CAG） were selected. According to CAG examination results, patients were divided into three groups： young CHD group（n=82, age≤45）, older CHD group（n=80, age≥60）, young control group（n=60, age≤45）. Statistical analysis was conducted on the clinical data of three groups with clinical parameters. The characteristics of coronary artery lesions between young CHD group and older CHD group were compared. The logistic regression analysis was used to detect the independent risk factors of young male patients with CHD. Results The older CHD group and the young control group have significant differences in some baseline data and some clinical indexes when compared with the young CHD group（P〈0. 05）. The coronary artery lesions in young CHD group more occurred in the single vessel which major in the left anterior descending artery. The proportion of Gensini score in the young CHD group was significantly higher than that in the elderly group CHD（P〈0. 05）, while the proportion of the Gensini score 60 point was significantly lower in the elderly group CHD（P〈0. 05）. Logistic regression analysis showed that smoking, hyperlipidemia, hypertension, diabetes, CHD family history were independent risk factors of CHD in young men compared with young control group. Conclusion smoking, hyperlipidemia, hypertension, type 2 diabetes, family history of premature CHD are independent risk factors for young male CHD. The coronary artery lesions in young CHD patients often occurred in the single vessel which major in the left anterior descending artery, and the range and extent of the lesions were lower than the old men.
出处
《中国循证心血管医学杂志》
2016年第2期229-232,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
青年男性
冠心病
危险因素
冠脉病变特点
Young man under the age of 45
Coronary heart disease
Risk factors
Coronary lesions
