摘要
目的探讨体外受精-胚胎移植(IVF-ET)与单胎妊娠早产风险的关系。方法选取2012年1月至2013年1月行IVF-ET并于北京大学第三医院助孕且分娩的单胎妊娠孕妇563例为研究组,其中女性因素不孕组(单纯女性因素或合并双方因素)369例、单纯男性因素不孕组150例,44例不明原因不孕;按年龄、孕产次配对同一时间段自然单胎妊娠的1126例孕妇为对照组,分析两组产科结局。结果研究组早产率显著高于对照组(11.90%vs.6.93%,P<0.05),妊娠期糖尿病、胎膜早破、前置胎盘、产后出血的发生率显著高于对照组,新生儿出生孕周显著低于对照组[(38.64±2.16)周vs.(39.12±1.73)周,P<0.05],低出生体重发生率显著高于对照组(8.34%vs.4.35%,P<0.05)。女性因素不孕组早产率显著高于单纯男性因素不孕组及对照组(12.74%vs.6.67%vs.6.93%,P<0.05);胎膜早破、产后出血发生率显著高于单纯男性因素不孕组(28.7%vs.11.33%,14.63%vs.6.67%,P<0.05),妊娠期糖尿病、胎盘早破、前置胎盘、产后出血发生率显著高于对照组(P<0.05);女性因素不孕组新生儿出生孕周显著低于单纯男性因素不孕组及对照组[(38.51±2.15)周vs.(38.97±1.85)周vs.(38.64±2.16)周,P<0.05)],低出生体重发生率显著高于对照组(8.94%vs.4.35%,P<0.05)。结论体外受精-胚胎移植患者单胎妊娠早产发生率增加,可能与引起女性不孕因素相关疾病及女性因素不孕妇女妊娠期并发症发生率增加相关。
Objective To investigate the relationship of the risk of premature delivery among singleton pregnancies with IVF-ET. Methods A group of 563 women who conceived by IVF-ET from January 2012 to January 2013 in obstetric ward of Peking University Third Hospital were chosen as the study group （IVF-ET group） , and 1126 women who gave birth during the same period of time in the same hospital were chosen as the case-control group （ nature conceived group or NC group） according to their mean maternal age, gravidity and parity. The IVF-ET group was divided into female-fac- tor （n=369）, the＂pure＂ male- factor infertility subgroups （n=150） and the unexplained infertility subgroup （n=44）. The pregnancy outcomes of these two groups were compared.Results The preterm delivery rate in IVF-ET group was sig- nificantly higher than control group （11.90% vs. 6.93%, P〈0.05 ）IVF-ET singleton pregnancies were associated with an increased risk of pregnancy-induced complications, such as gestationa mellitus diabetes, premature rupture of mem- branes, previa placenta and postpartum hemorrhages, with statistical significance （P〈0.05）. The perinatal mean gesta- tional week was lower than NC group [ （38.64±2.16）weeks vs. （39.12± 1.73）weeks, P〈0.05 ], while low birth weight rate was higher than NC group （8.34% vs. 4.35%, P〈0.05）. Within IVF-ET group, the incidence rates of prematurity, PROM, and postpartum hemorrhages in female-factor infertility group were significantly higher than the＂pure＇male infer- tility group （P〈0.05）. The incidence rates of gestational mellitus diabetes, premature rupture of membranes, previa pla- centa and postpartum hemorrhages in female-factor infertility group were significantly higher than NC group. The perina- tal mean gestational week was lower than ＂pure＂ male-factor infertility group and NC group, while low birth weight rate were higher than NC group （P〈0.05）.Conclusion The increased rate of prematurity of singleton IVF- ET pregnanciesis
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2017年第6期609-612,共4页
Chinese Journal of Practical Gynecology and Obstetrics
基金
首都卫生发展科研专项项目(首发2014-1-4091)
关键词
体外受精-胚胎移植
单胎
早产
in vitro fertilization and embryo transfer
singleton
prematurity
