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来曲唑治疗不同体质量指数多囊卵巢综合征患者的临床效果 被引量:7

Clinical effects of body mass index on ovulation induction treatment with letrozole among women with polycystic ovary syndrome
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摘要 目的比较不同体质量指数(BMI)的多囊卵巢综合征(PCOS)患者使用来曲唑促排卵的临床效果。方法将2014年1月至2015年12月于山东大学附属生殖医院就诊的153例有生育要求的PCOS患者作为研究对象,根据BMI将患者分为肥胖型组71例和非肥胖型组82例。在患者月经第2~4天开始给予来曲唑5 mg,次/d×5 d促排卵监测并指导同房;比较两组间的促排卵效果。结果肥胖型组的血糖、胰岛素、甘油三酯、高密度脂蛋白及总胆固醇水平高于非肥胖型组(P=0.020,<0.001,0.002,<0.001,0.028),而给予绒促性素(HCG)日雌二醇水平低于非肥胖型组,差异均有统计学意义(P=0.026)。两组患者的优势卵泡数、排卵率、HCG日子宫内膜厚度和促黄体生成素、孕酮等激素水平、妊娠率、流产率及活产率等的比较差异均无统计学意义(P>0.05)。结论不同BMI的PCOS患者可选用来曲唑促排卵,其可提高周期排卵率及妊娠率,肥胖型PCOS患者临床效果与非肥胖型患者相似。 Objective To compare the clinical effects of body mass index (BMI) on ovulation induction treatment with letrozole among women with polycystic ovary syndrome (PCOS). Methods A total of 153 infertile PCOS women treated during Jan. 2014 and Dec. 2015 were enrolled. These women were divided into obese group (n = 71 ) and non- obese group (n =82) according to their BMI. The stimulation was initiated by letrozole at a dose of 5mg daily for 5 days, beginning from day 2 to day 4 of the menstrual cycle. The ovulation induction outcomes of the two groups were compared. Results The obese group had significantly higher serum glucose, insulin, triglyceride, high density lipo- protein (HDL), and total cholesterol level than the non-obese group (P = 0.020, 〈 0. 001, = 0. 002, 〈 0. 001, = 0.028). On the day when human chorionic gonadotropin (HCG) was administered, estradiol (E2 ) was statistically lower in the obese group than in the non-obese group ( P = 0.026). There were no differences in the number of domi- nant follicles, ovulation rate, luteinizing hormone (LH) level on the HCG day, progesterone level, pregnancy rate, miscarriage rate and live birth rate between the two groups (P 〉 0.05). Conclusion Letrozole is an effective ovulation induction agent for infertile PCOS women with different MBI by improving the ovulation and pregnancy rate.
出处 《山东大学学报(医学版)》 CAS 北大核心 2017年第5期81-85,共5页 Journal of Shandong University:Health Sciences
基金 国家自然基金面上项目(81471428 81200423) 山东省医药卫生科技发展计划项目(2014WS0122) 山东省科技发展计划项目(2014GSF118148)
关键词 多囊卵巢综合征 来曲唑 体质量指数 肥胖 活产率 Polycystic ovary syndrome Letrozole Body mass index Obesity Live birth rate
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