摘要
研究了一种可快速拆分氧氟沙星的方法;该方法采用分子印迹技术,用二氧化硅包裹的Fe3O4磁性纳米颗粒为载体,再用手性试剂N-正辛基-D-葡萄糖胺作为单体,以氧氟沙星作为模板分子制备磁性表面分子印迹聚合物。该手性聚合物可与右旋氧氟沙星结合,最终分离出左旋氧氟沙星。最后利用外加磁场及透射电子显微镜对于所制备的氧氟沙星磁性分子印迹聚合物的性状进行检测;并对分离得到的左旋氧氟沙星进行旋光度的检测。
A method of quickly resolving ofloxacin using molecular imprinting technique was mainly researched on. Fe3O4 magnetic nanoparticles coated with silica is acted as the substrate. Chiral reagent is N-octyl-Dglucosamine as monomer, with ofloxacin as the template molecules to prepare magnetic surface molecularly imprinted polymer. The chiral polymer can be combined with dextral ofloxacin, eventually levofloxacin was isolated. Finally by using extermal magnetic field and transmission electron microscopy( TEM),the character of magnetic surface molecularly imprinted polymer is tested,and the levofloxacin is detected by optical rotation.
出处
《科学技术与工程》
北大核心
2017年第13期237-241,共5页
Science Technology and Engineering
基金
陕西省自然科学基础研究计划2014JQ2-8053
陕西省科技厅面上项目2016JM8095资助
关键词
磁性颗粒
表面分子印迹
分子印迹技术
磁性表面聚合物
手性分离
magnetic particles
surface molecular imprinting
molecular imprinting technique
the magnetic surface of the polymer
chiral separation