摘要
目的了解不同地区10~11岁儿童血铅水平和相关血清学指标的变化。方法选择无铅污染史的L山区和H岛屿以及附近有重工业的N工业区10~11岁儿童为研究对象,采集晨尿和外周静脉血,检测血铅(Pb B)、尿δ-氨基-γ-酮戊酸(ALA)、血清钙(Ca^(2+))、尿素氮(BUN)、肌酐(Cr)、促甲状腺素(TSH)、甲状腺素(T4)和游离甲状腺素(FT4)水平。结果 N工业区儿童Pb B中位数为36.0 ppb,高于H岛屿的23.8 ppb和L山区的22.0 ppb(均P<0.05)。三个监测点儿童的尿δ-ALA、血清BUN、Cr水平差异均无统计学意义(P>0.05)。N工业区儿童血清Ca^(2+)为(2.19±0.16)mmol/L,低于L山区的(2.47±0.15)mmol/L和H岛屿的(2.46±0.19)mmol/L(均P<0.05)。N工业区儿童血清T4为(99.2±11.8)nmol/L,低于L山区的(110.9±14.5)nmol/L和H岛屿的(110.2±18.2)nmol/L(均P<0.05);H岛屿儿童血清FT4为(17.3±2.1)pmol/L,高于L山区儿童的(16.0±2.5)pmol/L和N工业区的(14.8±1.7)pmol/L(均P<0.05);L山区儿童TSH为(3.99±1.74)m IU/L,高于N工业区的(2.65±1.03)m IU/L和H岛屿的(2.51±1.15)m IU/L(均P<0.05)。结论 N工业区儿童血铅水平较高,可能对儿童健康造成不良影响,应引起有关部门重视。
Objective To learn the changes of blood lead levels and serum biochemical parameters of the school age children from different areas. Methods All research objects, the school age children, were from three different areas respectively,including a mountainous area（L area）,an island area（H area） where there is not history of Pb pollution,and an industry area（N area） in relation to Pb pollution. The morning urine and peripheral venous blood samples were collected from the school age children. Pb in blood（Pb B）,δ-aminoaevulinic acid in urine（ALA）,Ca2＋,BUN,Cr in serum,and Thyroid Stimulating Hormone（TSH）,thyroxin（T4）,free thyroxin（FT4） levels were detected. Results Pb B levels [M was 36.0 ppb] of the school age children from N area were significantly higher than that of L area [22.0 ppb] and H area [23.8 ppb]. On the contrary,serum Ca2＋ levels of the school age children from N area were significantly lower than that of L area and H area. Serum T4 of N area was significantly lower than that of L area and H area. Serum FT4 of H area was significantly higher than that of L area and N area. And TSH of N area and H area were both obviously lower than that of L area.But all of these thyroxin indexes were in the range of normal values. Conclusion It should be widely concerned that the significant elevation of Pb B levels may have a negative impact on school age children in the future.
出处
《预防医学》
2017年第5期449-451,共3页
CHINA PREVENTIVE MEDICINE JOURNAL
关键词
血铅
血清学指标
甲状腺激素
儿童
Blood lead
Serum biochemical parameters
Thyroid hormones
