摘要
目的观察益肺平喘汤联合穴位贴敷治疗咳嗽变异性哮喘患儿的临床疗效及作用机制。方法将120例咳嗽变异性哮喘患儿随机分为观察组和对照组,各60例。对照组给予孟鲁司特治疗,观察组以益肺平喘汤联合穴位贴敷治疗。结果治疗后观察组患儿的临床症状评分低于对照组(P<0.05)。观察组的嗜酸性粒细胞阳离子蛋白(ECP)、IgE、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)水平显著低于对照组患儿(P<0.01);观察组患儿的有效率为96.67%,显著高于对照组的86.67%(P<0.05)。两组患儿CD4^+水平和CD4^+/CD8^+比值较前均有不同程度上升,CD8^+水平较前均有不同程度下降(P<0.01),且观察组上升或下降幅度明显大于对照组(P<0.01)。观察组患儿IgA、IgG水平较治疗前显著升高,IgE较治疗前显著下降(P<0.05)。对照组治疗前后IgA、IgM、IgG均无显著性差异(P>0.05),IgE较治疗前显著下降(P<0.05)。观察组治疗期间未见明显不良反应发生。结论益肺平喘汤联合穴位贴敷治疗咳嗽变异性哮喘患儿的临床效果显著优于西医疗法,其机制可能与能纠正患儿外周血T淋巴细胞亚群紊乱,上调血清CD4^+水平和CD4^+/CD8^+比值,下调CD8^+水平,激活并增强其细胞免疫功能和抑制机体炎症反应有关。
Objective： To discuss the clinical effect and mechanism of Yifei Pingchuan Decoction combined with point application therapy on children cough variant asthma. Methods： 120 cases of children patients with cough variant asthma in our hospital were randomly divided into observation group and control group with 60 cases in each group. The control group was treated with montelukast,the observation group was treated ;;＇ith Yifei Pingchuan Decoction combined with point application therapy. The curative effects in the two groups were observed, Results： The clinical symptoms scores in the observation group were significantly shorter than those in the control group（P〈 0.05）. Eosinophil cation protein （ECP）,immunoglobulin E （IgE）,interleukin-4 （IL-4）,inter- leukin-5 （IL-5） levels in the observation group were significantly lower than that in the control group （P〈 0.01 ）. The total effective rate in the observation group was 96.67% which was significantly higher than 86.67% in the control group （P 〈 0.05）. The CD4＋ level and CD4＋/CD8＋ ratio increased to different extents and CD8＋ level de- creased to different extents in the two groups （P〈 0.01 ）. The increase range or decrease range in the observation group was obviously bigger than that in the control group （P〈 0.01 ）. There was no significant difference on IgA, IgM and IgG in the control group after treatment （P 〉 0.05 ）, IgE decreased significantly after treatment （P 〈 0.05）. There was no obvious adverse reaction reported in the observation group during the treatment. Conclusion： Yifei Pingchuan Decoction combined with point application therapy has better clinical effect than western medicine therapy on children cough variant asthma. It mechanism may be related to correcting peripheral blood T lymphocyte subsets disorder, up-regulating serum CD4＋ level and CD4＋/CD8＋ ratio and down-regulating CD8＋ level, acti vating and strengthening the cellular immune function and inhibiting the inflamm
出处
《中国中医急症》
2017年第5期860-863,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
全国名老中医传承工作室(刘贵云)建设项目
关键词
小儿咳嗽变异性哮喘
益肺平喘汤
穴位贴敷
Children cougn variant asthma
Y if ei Pingchuan Decoction
Point application therapy
