摘要
TiO_2纳米管阵列具有规则的中空结构、较大的比表面积以及良好的生物相容性,有利于实现药物的填充及负载。本文通过阳极氧化法制备的TiO_2纳米管阵列,再通过水热的方法对纳米管进行改性,最后采用真空干燥法于TiO_2纳米管阵列负载亲水性的阿仑膦酸钠和疏水性的布洛芬,并考察了TiO_2纳米管阵列-亲疏水药物负载体系在磷酸盐缓冲溶液(PBS)中的释放行为。利用冷场发射扫描电镜(SEM)、X射线衍射仪(XRD)、以及紫外分光光度计(UV-VIS)等对试样进行表征。实验数据表明,改性的TiO_2纳米管阵列载入两种药物的量都有增加。改性后的纳米管的释放行为也包括前数小时较高释放量的快速释放阶段,但在后期的缓慢释放阶段改性后比未做任何改性的纳米管释放的更缓慢,结果表明改性后的纳米管具有一定的缓释效果。
TiO2 nanotube arrays possess regular hollow structure, large specific surface area and good biocompatibility, which are good for filling with drugs. A vertically aligned nanotube arrays of titanium oxide was fabricated on the surface of titanium substrate in fluoride-containing electrolytes by anodization. TiO2 nanotube arrays were modified with the method of hydrothermal. After that they were loaded with hydrophilic and hydrophobic drugs via vacuum drying method and the release of drugs from the nanotubes were detected in phosphate buffer solution （PBS）. The samples were characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, Fourier transform infrared （FTIR） and visible ultraviolet spectrophotometer （UV-vis）. The data showed that drug loading capacity of alendronate and ibuprofen were increased a lot, dugs from the modified nanotubes also included two stages： burst release and sustained release, but compared with unmodified nanotubes, modified nanotubes released drugs more slowly. The result indicated that the drug loaded in the modified Ti02 nanotubes had a certain amounts of sustained＇release effect.
出处
《广州化工》
CAS
2017年第9期47-49,共3页
GuangZhou Chemical Industry
基金
福建师范大学大学生创新创业训练计划项目资助
福建师范大学化学拔尖创新人才培养计划资助
