摘要
目的:探讨益肾活血方对糖尿病肾病患者凝血功能、血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)的影响,为治疗糖尿病肾病提供依据。方法:选择2010年2月—2015年3月在我院治疗的94例糖尿病肾病患者(气阴两虚兼瘀血),按治疗方法分为两组,对照组给予格列喹酮和诺和灵30R治疗,在对照组的基础上,研究组给予益肾活血方。治疗3月后,评价两组的临床疗效,对比治疗前后的肾功能、血糖、ET-1、CGRP、凝血功能,并观察在治疗过程中的不良反应。结果:(1)研究组总有效率为80.85%,高于对照组总有效率61.70%(P<0.05);(2)研究组治疗后的24 h尿微量蛋白、血肌酐、尿素氮、胱抑素c、同型半胱氨酸、空腹血糖、餐后2 h血糖、糖化血红蛋白较治疗前均出现减少(P均<0.05),且研究组治疗前后差值明显大于对照组的(P均<0.05);(3)两组治疗后的ET-1较治疗前均出现降低,CGRP较治疗前升高,差异显著(P均<0.05),且研究的ET-1、CGRP治疗前后差值明显大于对照组的,差异显著(P均<0.05);(4)两组治疗后的纤维蛋白原(FIB)较治疗前均出现降低,活化部分凝血活酶时间(APTT)较治疗前升高,差异显著(P均<0.05),且研究组的FIB、APTT治疗前后差值明显大于对照组的,差异显著(P均<0.05);(5)在治疗的过程中,两组均未出现不良反应。结论:益肾活血方对糖尿病肾病患者(气阴两虚兼瘀血)治疗效果较好,能有效地改善肾功能及血糖,这可能与调节凝血功能、血浆内皮素及降钙素基因相关肽有一定关系。
Objective： To investigate the influence of coagulant function, ET - 1 and CGRP in diabetic nephropathy patients with Qi and Yin deficiency and blood stasis by Yishen Huoxue Decoction and provide the basis for treatment of early diabetic nephropathy. Methods ： Ninety - four diabetic nephropathy patients with Qi and Yin deficiency and blood stasis from February 2010 to March 2015 in our hospital for the treatment were selected. According to the treatment, they were divided into two groups. The control group was given treatment of gliquidone and Novolin 30R. On the basis of con- trol group, research group was given Yishen Huoxue Decoction. After treatment of 3 months, the clinical effieets of two groups were evaluated. The renal function, blood glucose, ET - 1 and CGRP and coagulation function before and after treatment were compared between two groups and reactions in the treatment process were observed. Results ： （ 1 ） The total effective rate in research group was 80.85%, which was higher than the control group＇ s 61.70% （ P 〈 0.05）. （2） 24 h urinary micro protein, serum creatinine, blood urea nitrogen, the bladder inhibition C, homocysteine, fasting blood sugar, 2 h postprandial blood glucose and glycosylated hemoglobin after treatment reduced in research group （ P 〈 0. 05 ）. The difference before and after treatment in research group was significantly bigger than that in control group （ P 〈 0. 05）. （3） ET - 1 after treatment was reduced and CGRP increased （ P 〈 0. 05 ） and the difference of ET - 1 and CGRP before and after treatment in research group was significantly bigger than that in control group （ P 〈 0. 05）. （4） After treatment, fibrinogen （FIB） in the two groups was in the lower and part activated clotting time （APIT） live enzymes increased （ P 〈 0. 05 ） and the difference of FIB and AFTT before and after treatment in research group was signif- icantly bigger than that in control group （ P 〈 0. 05 ）. （5） In the process of trea
出处
《中华中医药学刊》
CAS
北大核心
2017年第5期1232-1235,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省教育厅科学技术研究重点项目(14A350011)
关键词
糖尿病肾病
益肾活血方
内皮素
降钙素基因
diabetic nephropathy
Yishen Huoxue Decoction
endothelin
calcitonin gene
