摘要
目的探讨阿托伐他汀与瑞舒伐他汀对急性心肌梗死患者心肌功能及血管内皮功能的影响。方法将2014年2月至2015年2月内蒙古医科大学附属医院收治的98例急性心肌梗死患者依据完全随机化分组法分为A组和B组,每组各49例,全部患者均给予基础治疗,A组患者加用瑞舒伐他汀,B组患者加用阿托伐他汀。比较两组患者治疗前后血脂、高敏C反应蛋白(high-sensitive C-reactive protein,hs-CRP)水平、血管内皮功能以及心功能指标。随访1.5年,比较两组患者不良心血管事件发生率。结果治疗后两组患者射血分数(ejection fractions,EF)、二尖瓣口血流速度(mitral orifice blood flow velocity,MV)、三尖瓣口血流速度(tricuspid orifice blood flow velocity,TV)、主动脉瓣口血流速度(aortic valve blood flow velocity,AV)组间比较差异均无显著性(P>0.05),但两组患者EF、MV、TV、AV均高于本组治疗前(P<0.05)。治疗后两组患者总胆固醇(total cholesterol,TC)、低密度脂蛋白(low-density lipoprotein,LDL)以及hs-CRP水平均低于本组治疗前(P<0.05),高密度脂蛋白(high density lipoprotein,HDL)水平高于本组治疗前(P<0.05);治疗后A组患者TC、LDL、hs-CRP水平均显著低于B组(P<0.05),HDL水平显著高于B组(P<0.05)。两组随访期间均无死亡病例,A组2例患者复发心绞痛,3例患者血运重建不良,心血管事件发生率为10.20%(5/49);B组3例患者复发心绞痛,4例患者血运重建不良,心血管事件发生率为14.29%(7/49),两组患者不良心血管事件发生率比较差异无显著性(P>0.05)。结论瑞舒伐他汀改善急性心肌梗死患者血脂及心脏功能优于阿托伐他汀。
Objective To investigate the effects of Atorvastatin and Rosuvastatin on myocardial function and vascular endothelial function in patients with acute myocardial infarction. Method 98 patients with acute myocardial infarction in the Affiliated Hospital of Inner Mongolia Medical University from February 2014 to February 2015 were randomly divided into group A and group B, each group of 49 cases. All patients were given basic treatment, patients in group A were treated with Rosuvastatin, and patiems in group B were treated with Atorvastatin. The levels of serum lipids, high sensitive C reactive protein （hs-CRP）, vascular endothelial function and cardiac function were compared between the two groups before and after treatment. Followed up for 1.5 years, the incidence of adverse cardiovascular events was compared between the two groups. Result After treatment, there were no significant differences in the ejection fraction （EF）, mitral orifice blood flow velocity （MV）, tricuspid orifice blood flow velocity （TV）, aortic valve blood flow velocity （AV） between the two groups （P 〉 0.05）, but EF, MV, TV, AV of the two groups were higher than those before treatment （P 〈 0.05）. After treatment totalcholesterol （TC）, low density lipoprotein （LDL） and hs-CRP levels of the two groups were lower than those before treatment （P 〈 0.05）; after treatment, TC, LDL and hs-CRP levels of group A were significantly lower than those of group B （P 〈 0.05）, high density lipoprotein （HDL） of group A was significantly higher than that in group B （P 〈 0.05）. There were no deaths during the follow-up period between the two groups, 2 patients with recurrent angina pectoris and 3 patients with poor revascularization in group A, the incidence of cardiovascular events was 10.20% （5/49）. 3 patients with recurrent angina pectoris and 4 patients with poor revascularization in group B, the incidence of cardiovascular events was 14.29% （7/49）, there was no significant difference in the
出处
《中国医学前沿杂志（电子版）》
2017年第3期68-71,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
阿托伐他汀
瑞舒伐他汀
急性心肌梗死
血管内皮功能
Atorvastatin
Rosuvastatin
Acute myocardial infarction
Vascular endothelial function
