摘要
目的观测妊娠11~13^(+6)周及妊娠22~24周胎儿下颌间隙的发育状况,探讨下颌间隙对预测小下颌畸形的临床意义。方法 360例行早孕、中孕期产前筛查孕妇,妊娠11~13^(+6)周测量头臀径(CRL),在鼻后三角切面测得下颌间隙;妊娠22~24周测量双顶径(BPD),在下颌骨长轴切面测量下颌间隙。分别以CRL、BPD作自变量,观察不同孕周下颌间隙的变化。结果早、中孕期测量下颌间隙的宽度切实可行,妊娠11~13^(+6)周胎儿下颌间隙宽度随头臀径(CRL)增加逐渐增加,呈线性相关,直线回归方程为Y=0.034X+0.157(r=0.532,P<0.05),差异有统计学意义;妊娠22~24周的胎儿下颌间隙宽度维持在一个稳定的范围内,95%的参考值范围为(2.59,5.99),妊娠22~24周下颌间隙中出现一个骨化点,形成2个小的间隙,随孕周增加,2个小的间隙逐渐缩小。结论早、中孕期胎儿下颌间隙测量具有可重复性,同时下颌间隙的变化规律可作为胎儿颜面部畸形筛查的一个参考标准,尤其在小下颌畸形筛查的方面具有重要的价值。
Objective To observe the development status and the significance of the fetal mandibular gapat 11-13^＋6weeks and 22-24 weeks of gestation. Methods Prenatal ultrasound screening was performed on 360 pregnant women at first trimester（ 11 to 13^＋6week, ） and second trimester（22-24 weeks＇） . Fetal crown rump length（ CRL） wasmeasured at 11-13^＋6weeks of gestation,thenthe mandibular- gapdistance was measuredaccording to the postnasal triangle view. Fetalbiparietal diameter（ BPD） wasmeasured at 22-24 weeks of gesta-tion, and then the mandibular-gapdistancewas measuredaccording to the long axis of the mandibular view. Finally,we usedthe CRL,BPD as independent variables to observe the changes of submandibular gapin different gestational age, respectively. Results The measure-ment method of the mandibular-gapdistance at first trimester and second trimester waseffective and feasible. There wassignificant linear correlation between themandibular-gapdistance and the CRL during 11-13^＋6gestational weeks. The linear regression equation was Y = 0. 034X ＋ 0. 157, （ r = 0. 532 ,P 〈 0. 05 ） was considered to have statistical significance ; the mandibular-gapdistance of pregnant 22-24 w was maintained in a stable range,95% reference value range（2. 59,5. 99）. There wasan ossification point in the mandibular gap of pregnant 22-24 w,which formed 2 small gap. With the increasingof gestational age,the 2 small gaps became gradually narrowing. Con-clusions The measurement method of the mandibular-gapdistanceat first trimester and second trimester wasrepeatable. At the same time, the change of the mandibular-gapdistanceas a reference standard for the screening of maxillofacial structural malformations, plays an importantrolein the ultrasonographyidentification of micrognathia.
出处
《安徽医药》
CAS
2017年第4期654-657,共4页
Anhui Medical and Pharmaceutical Journal
基金
安徽省卫生厅第二批科研计划项目(13FR027)
关键词
鼻后三角
下颌间隙
胎儿
Posterior triangle of the nose
Mandibular gap
Fetus
