摘要
目的:探讨腺苷蛋氨酸辅助治疗妊娠期肝内胆汁淤积症的疗效。方法:选取2014年5月—2016年5月江西省婺源县妇幼保健院收治的妊娠期肝内胆汁淤积症患者122例作为研究对象,以随机数字表法分为观察组和对照组,每组61例。对照组患者给予常规治疗及熊去氧胆酸治疗,观察组患者在对照组基础上加用腺苷蛋氨酸治疗。观察2组患者治疗后的皮肤瘙痒程度、血清生化指标水平、剖宫产率及新生儿早产率和体质量。结果:治疗后,观察组患者的皮肤瘙痒评分为(1.32±0.45)分,明显低于对照组的(1.89±1.02)分;观察组患者血清总胆红素、血清总胆汁酸、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平明显低于对照组,差异均有统计学意义(P<0.05)。观察组患者剖宫产率、新生儿早产率明显低于对照组,新生儿体质量明显高于对照组,差异均有统计学意义(P<0.05)。结论:腺苷蛋氨酸辅助治疗妊娠期肝内胆汁淤积症的疗效显著,可明显改善患者预后。
OBJECTIVE： To probe into the efficacy of adenosine methionine in treatment of intrahepatic cholestasis of pregnancy（ ICP）. METHODS： 122 patients with ICP admitted into Jiangxi Wuyuan County Maternal and Child Health Hospital from May 2014 to May 2016 were selected to be divided into observation group and control group via the random number table,with 61 cases in each. The control group were treated with conventional treatment and adenosine methionine,while the observation group additionally received adenosine methionine based on the control group. The itch score,biochemical index changes in serum,incidence of premature delivery,the weight of newborns and the incidence of neonatal asphyxia of two groups were observed. RESULTS： After treatment,the itch score of observation group was（ 1. 32 ±0. 45） scores,significantly lower than that of control group [（ 1. 89 ± 1. 02） scores],and the level of serum total bilirubin,serum total bile acid,alanine aminotransferase and aspartate amino transferase in observation group were significantly lower than those of control group,with statistically significant difference（ P〈0. 05）. After delivery,the rate of cesarean section delivery and incidence of premature delivery in observation group were significantly lower than those of control group,while the weight of newborns were significantly higher that of control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of adenosine methionine in treatment of intrahepatic cholestasis of pregnancy is remarkable,which can significantly improve the prognosis of patients.
出处
《中国医院用药评价与分析》
2017年第3期351-352,355,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
腺苷蛋氨酸
熊去氧胆酸
胆汁淤积症
Adenosine methionine
Ursodeoxycholic acid
Intrahepatic cholestasis of pregnancy
