摘要
目的:考察吲哚美辛(IDM)肠溶滴丸中IDM存在的状态及与基质聚乙二醇6000(PEG 6000)的相互作用。方法:分别采用差示扫描量热法(DSC)、红外光谱法(IR)、X-射线衍射法及扫描电镜(SEM)观察对IDM、PEG 6000、两者的物理混合物及IDM肠溶滴丸进行研究。结果:DSC图谱中,IDM肠溶滴丸在164℃处的吸热峰消失,而57℃处的PEG 6000吸热峰发生了前移;IR图谱中,IDM肠溶滴丸中IDM的羰基伸缩振动峰消失,而在1 680 cm^(-1)处出现了新峰;X-射线衍射图谱中,IDM肠溶滴丸无衍射峰存在;SEM下IDM以更细小的状态分布于基质中。结论:IDM肠溶滴丸中IDM以无定形或分子形式分散于基质中,且IDM与PEG 6000发生了以氢键为主的化学作用。
Objective： To study the status of indomethacin （IDM） in 1DM enteric-coated dropping pills and its interaction with PEG 6000. Methods： IDM, PEG 6000, their physical mixture and IDM enteric-coated dropping pills were respectively studied by DSC, IR, X-ray diffraction and SEM. Results： In the map of DSC, the endothermic peak of IDM enteric-coated dropping pills disappeared at 164℃, and the endothermic peak of PEG 6000 at 57℃ shifted forward. In the map of IR, the carbonyl stretching vibration peak of IDM in IDM enteric-coated dropping pills disappeared, and a new peak appeared at 1 680 cm ^- 1. In the map of X-ray diffrac- tion, there was no diffraction peak in IDM enteric-coated dropping pills. SEM showed the morphology of IDM in the base was much smaller than that of IDM raw material. Conclusion ： IDM in IDM enteric-coated dropping pills is dispersed in the matrix with an amorphous or molecular form, and there is hydrogen bond between IDM and PEG 6000.
出处
《中国药师》
CAS
2017年第5期914-916,共3页
China Pharmacist
关键词
吲哚美辛
肠溶
滴丸
表征
Indometacin
Enteric-coated
Dropping pills
Characterization
