摘要
采用化学交联法制备叶酸-羧甲基壳聚糖偶联物(FCC),用于装载抗癌药物阿霉素,形成具有肿瘤靶向功能的自组装纳米粒(DOX-FCC NPs),并对载药纳米粒的体外释放特性进行了研究.结果表明,纳米粒呈球形,粒径约为200nm,包封率和载药量受到药物加入量的影响.该纳米粒具有良好的pH敏感释药特性,叶酸修饰可以增强药物在肿瘤部位的蓄积,减少对正常组织的毒性,达到靶向递药的效果.
Folate （FA） modified carboxymethyl chitosan （FCC） has been synthesized by chemical crosslinking method, and doxorubicin （DOX） loaded FCC nanoparticles （NPs） were prepared by sell assembly, which has the ability of targeting the tumor cells. Results showed that the nanoparticles were spherical and the particle size was about 200 nm. The drug loading content （DLC） and encapsulation efficiency （EE） were both affected by the adding DOX. The in vitro release showed that the NPs had a good pH-sensitive and sustained release for DOX. FA could enhance the DOX enrichment in the tumor cells, and reduce the toxicity for the normal tissues, which could improve the therapeutic effect of the tumor.
出处
《沈阳大学学报（自然科学版）》
CAS
2017年第2期87-90,共4页
Journal of Shenyang University：Natural Science
基金
国家自然科学基金资助项目(81503014)
关键词
叶酸
羧甲基壳聚糖
阿霉素
纳米粒
自组装
folate carboxymethyl chitosan doxorubicin nanoparticle
self-assembly
